Transepithelial transport of nicotine and vinblastine in isolated malpighian tubules of the tobacco hornworm (Manduca sexta) suggests a P-glycoprotein-like mechanism

We have examined the accumulative transport properties of the Malpighian (excretory) tubules of the tobacco hornworm Manduca sexta to test the hypothesis that a P-glycoprotein-like multidrug transporter is active and is responsible for the excretion of dietary nicotine in this tissue. Isolated tubul...

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Veröffentlicht in:	Journal of experimental biology 1998-09, Vol.201 (Pt 18), p.2637-2645
Hauptverfasser:	Gaertner, L S, Murray, C L, Morris, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Atropine - pharmacology Biological Transport - drug effects Epithelium - metabolism Malpighian Tubules - metabolism Manduca - metabolism Nicotine - metabolism Verapamil - pharmacology Vinblastine - metabolism
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