Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care
Perinatal asphyxia may be severe and affect the neurological system, causing hypoxic ischaemic encephalopathy (HIE). Twenty-three term infants with HIE were studied over 3.5 years. Nine died and of the 14 survivors, eight were normal and the rest had abnormal neurological sequelae. Favourable progno...
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| Veröffentlicht in: | Journal of tropical pediatrics (1980) 1999-08, Vol.45 (4), p.229-232 |
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| container_title | Journal of tropical pediatrics (1980) |
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| creator | Toh, V Rajadurai, VS |
| description | Perinatal asphyxia may be severe and affect the neurological system, causing hypoxic ischaemic encephalopathy (HIE). Twenty-three term infants with HIE were studied over 3.5 years. Nine died and of the 14 survivors, eight were normal and the rest had abnormal neurological sequelae. Favourable prognostic markers were a 5 minute Apgar score (>5, first pH >7.1, and stage I HIE. Despite standard neonatal intensive care management, the mortality and morbidity rates for these infants remained high. |
| doi_str_mv | 10.1093/tropej/45.4.229 |
| format | Article |
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Twenty-three term infants with HIE were studied over 3.5 years. Nine died and of the 14 survivors, eight were normal and the rest had abnormal neurological sequelae. Favourable prognostic markers were a 5 minute Apgar score (>5, first pH >7.1, and stage I HIE. Despite standard neonatal intensive care management, the mortality and morbidity rates for these infants remained high.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/45.4.229</identifier><identifier>PMID: 10467835</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Asphyxia Neonatorum - complications ; Asphyxia Neonatorum - diagnosis ; Asphyxia Neonatorum - mortality ; Asphyxia Neonatorum - therapy ; Biological and medical sciences ; Brain Damage, Chronic - epidemiology ; Brain Damage, Chronic - etiology ; Brain Ischemia - complications ; Brain Ischemia - diagnosis ; Brain Ischemia - mortality ; Brain Ischemia - therapy ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Humans ; Hypoxia, Brain - complications ; Hypoxia, Brain - diagnosis ; Hypoxia, Brain - mortality ; Hypoxia, Brain - therapy ; Infant, Newborn ; Intensive care medicine ; Intensive Care, Neonatal ; Medical sciences ; Prognosis ; Singapore - epidemiology ; Tropical medicine</subject><ispartof>Journal of tropical pediatrics (1980), 1999-08, Vol.45 (4), p.229-232</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Aug 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-505a64c84450c07ed6d11d403a97d10cd7a8c9230c899aaa2475aa274c5cfa943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1905465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10467835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toh, V</creatorcontrib><creatorcontrib>Rajadurai, VS</creatorcontrib><title>Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>Perinatal asphyxia may be severe and affect the neurological system, causing hypoxic ischaemic encephalopathy (HIE). Twenty-three term infants with HIE were studied over 3.5 years. Nine died and of the 14 survivors, eight were normal and the rest had abnormal neurological sequelae. Favourable prognostic markers were a 5 minute Apgar score (>5, first pH >7.1, and stage I HIE. Despite standard neonatal intensive care management, the mortality and morbidity rates for these infants remained high.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Asphyxia Neonatorum - complications</subject><subject>Asphyxia Neonatorum - diagnosis</subject><subject>Asphyxia Neonatorum - mortality</subject><subject>Asphyxia Neonatorum - therapy</subject><subject>Biological and medical sciences</subject><subject>Brain Damage, Chronic - epidemiology</subject><subject>Brain Damage, Chronic - etiology</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - mortality</subject><subject>Brain Ischemia - therapy</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Humans</subject><subject>Hypoxia, Brain - complications</subject><subject>Hypoxia, Brain - diagnosis</subject><subject>Hypoxia, Brain - mortality</subject><subject>Hypoxia, Brain - therapy</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Intensive Care, Neonatal</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Singapore - epidemiology</subject><subject>Tropical medicine</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0UuLFDEQAOBGFHd29exNgsjeeibPfniTQV1lwcuoi5dQpquZjN1Jm6TXHfDHm6UHFS9JSL6qVFJF8YzRNaOt2KTgJzxspFrLNeftg2LFZKVKUVXyYbGiTPKyEqI5K85jPFBKeSPl4-KMUVnVjVCr4tcOw0is68GlSH7atCf74-TvrCE2mj3gmFfoDE57GPwEaX98RSbvA3E4B9_hLebtEV2Cgfg5GT8i6TBONiGJCVwHocvWO7gX1iV00d4iMRDwSfGohyHi09N8UXx6-2a3vSqvP757v319XRrJm1QqqqCSJpeuqKE1dlXHWCepgLbuGDVdDY1puaCmaVsA4LJWeaylUaaHVoqL4nLJOwX_Y8aY9Jgfh8MAubA56jr_DFOsyvDFf_Dg5-BybZpzKUS-g2e0WZAJPsaAvZ6CHSEcNaP6vit66YqWSssc1-aI56e087cRu3_80oYMXp4ARANDH8AZG_-6lqrc1szKhdmY8O7PMYTvuqpFrfTVzVfNd-zD55tqq7-I31tyqEg</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Toh, V</creator><creator>Rajadurai, VS</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care</title><author>Toh, V ; Rajadurai, VS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-505a64c84450c07ed6d11d403a97d10cd7a8c9230c899aaa2475aa274c5cfa943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Asphyxia Neonatorum - complications</topic><topic>Asphyxia Neonatorum - diagnosis</topic><topic>Asphyxia Neonatorum - mortality</topic><topic>Asphyxia Neonatorum - therapy</topic><topic>Biological and medical sciences</topic><topic>Brain Damage, Chronic - epidemiology</topic><topic>Brain Damage, Chronic - etiology</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - mortality</topic><topic>Brain Ischemia - therapy</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Humans</topic><topic>Hypoxia, Brain - complications</topic><topic>Hypoxia, Brain - diagnosis</topic><topic>Hypoxia, Brain - mortality</topic><topic>Hypoxia, Brain - therapy</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Intensive Care, Neonatal</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Singapore - epidemiology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toh, V</creatorcontrib><creatorcontrib>Rajadurai, VS</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toh, V</au><au>Rajadurai, VS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>45</volume><issue>4</issue><spage>229</spage><epage>232</epage><pages>229-232</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>Perinatal asphyxia may be severe and affect the neurological system, causing hypoxic ischaemic encephalopathy (HIE). Twenty-three term infants with HIE were studied over 3.5 years. Nine died and of the 14 survivors, eight were normal and the rest had abnormal neurological sequelae. Favourable prognostic markers were a 5 minute Apgar score (>5, first pH >7.1, and stage I HIE. Despite standard neonatal intensive care management, the mortality and morbidity rates for these infants remained high.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10467835</pmid><doi>10.1093/tropej/45.4.229</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 1999-08, Vol.45 (4), p.229-232 |
| issn | 0142-6338 1465-3664 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70001516 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asphyxia Neonatorum - complications Asphyxia Neonatorum - diagnosis Asphyxia Neonatorum - mortality Asphyxia Neonatorum - therapy Biological and medical sciences Brain Damage, Chronic - epidemiology Brain Damage, Chronic - etiology Brain Ischemia - complications Brain Ischemia - diagnosis Brain Ischemia - mortality Brain Ischemia - therapy Emergency and intensive care: neonates and children. Prematurity. Sudden death Humans Hypoxia, Brain - complications Hypoxia, Brain - diagnosis Hypoxia, Brain - mortality Hypoxia, Brain - therapy Infant, Newborn Intensive care medicine Intensive Care, Neonatal Medical sciences Prognosis Singapore - epidemiology Tropical medicine |
| title | Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care |
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