Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents

Simple, safe and quick in vivo methods for estimating chemical uptake into the stratum corneum (SC) from volatile and non-volatile solvents are invaluable to health risk assessors. This study compares the human in vivo SC uptake of a model compound (4-cyanophenol) from water and acetone using quanti...

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Veröffentlicht in:	Pharmaceutical research 1999-08, Vol.16 (8), p.1288-1293
Hauptverfasser:	STINCHCOMB, A. L, PIROT, F, TOURAILLE, G. D, BUNGE, A. L, GUY, R. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Biological and medical sciences Epidermis - metabolism Forearm - physiology General pharmacology Humans Medical sciences Monoamine Oxidase Inhibitors - pharmacokinetics Pharmacology. Drug treatments Phenols - pharmacokinetics Skin Absorption Solvents - chemistry Spectroscopy, Fourier Transform Infrared Volatilization
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