UDP-glucuronosyltransferase (UGT1A128 and UGT1A62) polymorphisms in Caucasians and Asians : relationships to serum bilirubin concentrations

Polymorphisms that alter UDP-glucuronosyltransferase (UGT) activities have been identified. Mutations in the promoter of the UGT1A1 gene (UGT1A1*28), resulting in 5, 7 or 8, instead of 6 thymine-adenine (TA) repeats, alter bilirubin conjugation. Two missense mutations on one allele of UGT1A6 (UGT1A6...

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Veröffentlicht in:	Pharmacogenetics (London) 1999-06, Vol.9 (3), p.341-349
Hauptverfasser:	LAMPE, J. W, BIGLER, J, HORNER, N. K, POTTER, J. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Base Sequence Bilirubin - blood Biological and medical sciences Biotransformation Classical genetics, quantitative genetics, hybrids Cross-Sectional Studies Dinucleotide Repeats DNA Primers European Continental Ancestry Group - genetics Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glucuronosyltransferase - genetics Heterozygote Homozygote Human Humans Male Polymorphism, Genetic Promoter Regions, Genetic
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