Receptor-independent Activation of Atrial Muscarinic Potassium Channels in the Absence of Nucleotides

The removal of nucleotides from the solution bathing the inner face of excised patches of frog atrial membranes was found to activate muscarinic K+ channels in the absence of agonists. Channel activation was also observed in Mg2+-free solutions and blocked by low (0.1–10 μm) concentrations of GDP or...

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Veröffentlicht in:	The Journal of biological chemistry 1998-10, Vol.273 (44), p.28868-28872
Hauptverfasser:	Otero, Angelade S., Xu, Lan, Ni, Yajun, Szabo, Gabor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Freshwater Guanosine Diphosphate - metabolism Guanosine Triphosphate - metabolism Heart Atria - drug effects Heart Atria - metabolism Ion Channel Gating Muscarinic Agonists - pharmacology Potassium Channels - metabolism Rana Rana catesbeiana Receptors, Muscarinic - metabolism
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