Early infections after autologous transplantation for haematological malignancies
The purpose of this study was to evaluate the early infectious complications following autologous transplantation in haematological patients. Sixty-one patients who underwent either autologous bone marrow (BM; 28 patients) or peripheral blood stem cell (PBSC; 33 patients) transplantation for haemato...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 1998-07, Vol.15 (2), p.103-108 |
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| creator | SCHIØDT, I BERGMANN, O. J JOHNSEN, H. E HANSEN, N. E |
| description | The purpose of this study was to evaluate the early infectious complications following autologous transplantation in haematological patients. Sixty-one patients who underwent either autologous bone marrow (BM; 28 patients) or peripheral blood stem cell (PBSC; 33 patients) transplantation for haematological malignancies were reviewed retrospectively. Engraftment happened significantly faster and the length of hospital stay was shorter in the PBSC group compared with the BM group. All patients in the study developed fever and all but two experienced temperatures > or = 38.5 degrees C. Overall, 57 patients had signs of oral mucositis, 23 with ulceration. Twenty patients had bacteraemia, 12 developed pneumonia, 6 systemic fungal infection. No major differences were found between the two groups in distribution or incidence of infections. This study indicates that the use of peripheral blood stem cells results in faster engraftment and shorter hospital stay, whereas the effect on the incidence of early infections seems to be unaffected. |
| doi_str_mv | 10.1007/BF02989587 |
| format | Article |
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Graft versus host reaction ; Female ; Gram-Negative Bacterial Infections - etiology ; Gram-Positive Bacterial Infections - etiology ; Hematologic Neoplasms - therapy ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Infections - etiology ; Male ; Medical sciences ; Middle Aged ; Mycoses - etiology ; Oncology ; Retrospective Studies ; Time Factors ; Transfusions. Complications. Transfusion reactions. 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Graft versus host reaction</subject><subject>Female</subject><subject>Gram-Negative Bacterial Infections - etiology</subject><subject>Gram-Positive Bacterial Infections - etiology</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Infections - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses - etiology</subject><subject>Oncology</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. 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Graft versus host reaction</topic><topic>Female</topic><topic>Gram-Negative Bacterial Infections - etiology</topic><topic>Gram-Positive Bacterial Infections - etiology</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Infections - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycoses - etiology</topic><topic>Oncology</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHIØDT, I</creatorcontrib><creatorcontrib>BERGMANN, O. J</creatorcontrib><creatorcontrib>JOHNSEN, H. E</creatorcontrib><creatorcontrib>HANSEN, N. 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| ispartof | Medical oncology (Northwood, London, England), 1998-07, Vol.15 (2), p.103-108 |
| issn | 1357-0560 1559-131X |
| language | eng |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood cancer Bone Marrow Transplantation - adverse effects Bone marrow, stem cells transplantation. Graft versus host reaction Female Gram-Negative Bacterial Infections - etiology Gram-Positive Bacterial Infections - etiology Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation - adverse effects Humans Infections - etiology Male Medical sciences Middle Aged Mycoses - etiology Oncology Retrospective Studies Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Autologous |
| title | Early infections after autologous transplantation for haematological malignancies |
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