NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion

The NADH shuttle system is composed of the glycerol phosphate and malate-aspartate shuttles. We generated mice that lack mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), a rate-limiting enzyme of the glycerol phosphate shuttle. Application of aminooxyacetate, an inhibitor of the malate-aspa...

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Veröffentlicht in:	The Journal of biological chemistry 1999-09, Vol.274 (36), p.25386-25392
Hauptverfasser:	Eto, K, Suga, S, Wakui, M, Tsubamoto, Y, Terauchi, Y, Taka, J, Aizawa, S, Noda, M, Kimura, S, Kasai, H, Kadowaki, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cytosol - metabolism Glucose - pharmacology Glycerolphosphate Dehydrogenase - genetics Glycerolphosphate Dehydrogenase - metabolism Insulin - metabolism Insulin Secretion Islets of Langerhans - physiology Membrane Potentials Mice Mice, Knockout NAD - metabolism Potassium Channels - physiology
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