Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor–related peptides

Background & Aims: Posttranslational farnesylation is required for Ras activation. Farnesyl transferase inhibitors (FTIs) selectively block protein farnesylation and reduce the growth of many Ras-transformed cells in vitro and in vivo. Activated Ras transforms rat intestinal epithelial (RIE-1) c...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1999-09, Vol.117 (3), p.567-576
Hauptverfasser:	Sizemore, Nywana, Cox, Adrienne D., Barnard, John A., Oldham, Sean M., Reynolds, Evangeline R., Der, Channing J., Coffey, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Cell Line, Transformed Chemotherapy Down-Regulation - drug effects Enzyme Inhibitors - pharmacology ErbB Receptors - antagonists & inhibitors Intestinal Mucosa - cytology Ligands Medical sciences Pharmacology. Drug treatments Protein Prenylation - drug effects ras Proteins - metabolism Rats
Online-Zugang:	Volltext
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