Gamma‐irradiation does not impair ATRA‐induced maturation of myeloid leukaemic cells: implication for combined radiation and differentiation therapy

In the present study we investigated the effects of various doses of γ‐irradiation, followed by induction of granulocytic differentiation with all‐trans‐retinoic acid (ATRA), on proliferative rate, differentiation capability and oxidative metabolism of leukaemic cells from two different myeloid leuk...

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Veröffentlicht in:	British journal of haematology 1998-10, Vol.103 (1), p.79-86
Hauptverfasser:	Neildez‐Nguyen, Thi My Anh, Chapel, Alain, Arock, Michel, Vétillard, Jérôme, Thierry, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ATRA Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - radiation effects Cell Division - drug effects Cell Division - radiation effects Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) differentiation Gamma Rays - therapeutic use Hematology HL-60 Cells Humans leukaemia Leukemia, Myeloid - drug therapy Leukemia, Myeloid - radiotherapy Medical sciences Pharmacology. Drug treatments radiotherapy Tretinoin - therapeutic use γ‐irradiation
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