The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation
Inherited resistance to activated protein C is a thrombophilic condition resulting from a mutant factor V (factor V Leiden). 1 The mutation is relatively common among whites, with a frequency of 5 percent in the general population of European ancestry and 11 to 21 percent among patients with venous...
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| Veröffentlicht in: | The New England journal of medicine 1999-09, Vol.341 (11), p.801-806 |
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| container_title | The New England journal of medicine |
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| creator | De Stefano, Valerio Martinelli, Ida Mannucci, Pier Mannuccio Paciaroni, Katia Chiusolo, Patrizia Casorelli, Ida Rossi, Elena Leone, Giuseppe |
| description | Inherited resistance to activated protein C is a thrombophilic condition resulting from a mutant factor V (factor V Leiden).
1
The mutation is relatively common among whites, with a frequency of 5 percent in the general population of European ancestry and 11 to 21 percent among patients with venous thromboembolism.
2
The estimated risk of deep venous thrombosis is 7 times as high among heterozygous carriers of the mutation as among persons without the mutation, and 80 times as high among homozygotes.
3
There is disagreement whether factor V Leiden is associated with an increased risk of recurrent deep venous thrombosis. Several studies . . . |
| doi_str_mv | 10.1056/NEJM199909093411104 |
| format | Article |
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1
The mutation is relatively common among whites, with a frequency of 5 percent in the general population of European ancestry and 11 to 21 percent among patients with venous thromboembolism.
2
The estimated risk of deep venous thrombosis is 7 times as high among heterozygous carriers of the mutation as among persons without the mutation, and 80 times as high among homozygotes.
3
There is disagreement whether factor V Leiden is associated with an increased risk of recurrent deep venous thrombosis. Several studies . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199909093411104</identifier><identifier>PMID: 10477778</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Blood vessels ; Child ; Cohort Studies ; Disease-Free Survival ; Factor V - genetics ; Female ; Genetics ; Health risk assessment ; Hematologic and hematopoietic diseases ; Heterozygote ; Humans ; Incidence ; Male ; Medical disorders ; Medical sciences ; Middle Aged ; Mutation ; Platelet diseases and coagulopathies ; Point Mutation ; Prothrombin - genetics ; Recurrence ; Retrospective Studies ; Risk ; Risk Factors ; Venous Thrombosis - epidemiology ; Venous Thrombosis - genetics</subject><ispartof>The New England journal of medicine, 1999-09, Vol.341 (11), p.801-806</ispartof><rights>Copyright © 1999 Massachusetts Medical Society. All rights reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-d617f04e8976edb3a58087bade2ffb56c071ad4cae129b234f01cd26121562523</citedby><cites>FETCH-LOGICAL-c593t-d617f04e8976edb3a58087bade2ffb56c071ad4cae129b234f01cd26121562523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199909093411104$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223937641?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1937006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10477778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Stefano, Valerio</creatorcontrib><creatorcontrib>Martinelli, Ida</creatorcontrib><creatorcontrib>Mannucci, Pier Mannuccio</creatorcontrib><creatorcontrib>Paciaroni, Katia</creatorcontrib><creatorcontrib>Chiusolo, Patrizia</creatorcontrib><creatorcontrib>Casorelli, Ida</creatorcontrib><creatorcontrib>Rossi, Elena</creatorcontrib><creatorcontrib>Leone, Giuseppe</creatorcontrib><title>The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Inherited resistance to activated protein C is a thrombophilic condition resulting from a mutant factor V (factor V Leiden).
1
The mutation is relatively common among whites, with a frequency of 5 percent in the general population of European ancestry and 11 to 21 percent among patients with venous thromboembolism.
2
The estimated risk of deep venous thrombosis is 7 times as high among heterozygous carriers of the mutation as among persons without the mutation, and 80 times as high among homozygotes.
3
There is disagreement whether factor V Leiden is associated with an increased risk of recurrent deep venous thrombosis. Several studies . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Disease-Free Survival</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Genetics</subject><subject>Health risk assessment</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Platelet diseases and coagulopathies</subject><subject>Point Mutation</subject><subject>Prothrombin - genetics</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - genetics</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtv1DAUhS0EotOWX4CELITYoFC_4sTLdugDNG1RNXQbOc5Nx8PEHmxn0e753ziakUAIcb3wwt85x_ZB6DUlHykp5cnN-ZdrqpQieXFBKSXiGZrRkvNCCCKfoxkhrC5EpfgBOoxxTfJQoV6ig4xWeeoZ-rlcAb6z8Tv2Pb4DM4YALuFPAFt8D86PES9XwQ-tjzZiPXj3gK8gQfBPjw_T6VyHYCHESX_m0wpfaJN8wPd4AbYDh7XrcMohl4wwSk7x15CpydE6fD0mnax3x-hFrzcRXu33I_Tt4nw5vyoWt5ef56eLwpSKp6KTtOqJgFpVErqW67ImddXqDljft6U0pKK6E0YDZaplXPSEmo5JymgpWcn4EXq_890G_2OEmJrBRgObjXaQH9PI_J1SkQl8-xe49mNw-W4NY1zxSgqaIb6DTPAxBuibbbCDDo8NJc1UUfOPirLqzd56bAfo_tDsOsnAuz2go9GbPmhnbPzN5XRCZMY-7LBhiI2D9fDf1F-ECaQF</recordid><startdate>19990909</startdate><enddate>19990909</enddate><creator>De Stefano, Valerio</creator><creator>Martinelli, Ida</creator><creator>Mannucci, Pier Mannuccio</creator><creator>Paciaroni, Katia</creator><creator>Chiusolo, Patrizia</creator><creator>Casorelli, Ida</creator><creator>Rossi, Elena</creator><creator>Leone, Giuseppe</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990909</creationdate><title>The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation</title><author>De Stefano, Valerio ; Martinelli, Ida ; Mannucci, Pier Mannuccio ; Paciaroni, Katia ; Chiusolo, Patrizia ; Casorelli, Ida ; Rossi, Elena ; Leone, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-d617f04e8976edb3a58087bade2ffb56c071ad4cae129b234f01cd26121562523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood vessels</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Disease-Free Survival</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Genetics</topic><topic>Health risk assessment</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical disorders</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Platelet diseases and coagulopathies</topic><topic>Point Mutation</topic><topic>Prothrombin - genetics</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Stefano, Valerio</creatorcontrib><creatorcontrib>Martinelli, Ida</creatorcontrib><creatorcontrib>Mannucci, Pier Mannuccio</creatorcontrib><creatorcontrib>Paciaroni, Katia</creatorcontrib><creatorcontrib>Chiusolo, Patrizia</creatorcontrib><creatorcontrib>Casorelli, Ida</creatorcontrib><creatorcontrib>Rossi, Elena</creatorcontrib><creatorcontrib>Leone, Giuseppe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Stefano, Valerio</au><au>Martinelli, Ida</au><au>Mannucci, Pier Mannuccio</au><au>Paciaroni, Katia</au><au>Chiusolo, Patrizia</au><au>Casorelli, Ida</au><au>Rossi, Elena</au><au>Leone, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1999-09-09</date><risdate>1999</risdate><volume>341</volume><issue>11</issue><spage>801</spage><epage>806</epage><pages>801-806</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Inherited resistance to activated protein C is a thrombophilic condition resulting from a mutant factor V (factor V Leiden).
1
The mutation is relatively common among whites, with a frequency of 5 percent in the general population of European ancestry and 11 to 21 percent among patients with venous thromboembolism.
2
The estimated risk of deep venous thrombosis is 7 times as high among heterozygous carriers of the mutation as among persons without the mutation, and 80 times as high among homozygotes.
3
There is disagreement whether factor V Leiden is associated with an increased risk of recurrent deep venous thrombosis. Several studies . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>10477778</pmid><doi>10.1056/NEJM199909093411104</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1999-09, Vol.341 (11), p.801-806 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adolescent Adult Aged Biological and medical sciences Blood vessels Child Cohort Studies Disease-Free Survival Factor V - genetics Female Genetics Health risk assessment Hematologic and hematopoietic diseases Heterozygote Humans Incidence Male Medical disorders Medical sciences Middle Aged Mutation Platelet diseases and coagulopathies Point Mutation Prothrombin - genetics Recurrence Retrospective Studies Risk Risk Factors Venous Thrombosis - epidemiology Venous Thrombosis - genetics |
| title | The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation |
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