Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature
Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been r...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 1998-09, Vol.20 (5), p.494-497 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | SPURNEY, C GORLICK, R MEYERS, P. A HEALEY, J. H HUVOS, A. G |
| description | Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported.
A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma.
The patient was treated with anti-CD20 monoclonal antibody and is in complete remission.
This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy. |
| doi_str_mv | 10.1097/00043426-199809000-00018 |
| format | Article |
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A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma.
The patient was treated with anti-CD20 monoclonal antibody and is in complete remission.
This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/00043426-199809000-00018</identifier><identifier>PMID: 9787328</identifier><identifier>CODEN: JPHOFG</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - therapeutic use ; Antigens, CD20 - immunology ; Biological and medical sciences ; Bone Neoplasms - drug therapy ; Bone Neoplasms - pathology ; Bone Neoplasms - physiopathology ; Dermatology ; Female ; Humans ; Infant, Newborn ; Lymphoma, Non-Hodgkin - drug therapy ; Lymphoma, Non-Hodgkin - pathology ; Lymphoma, Non-Hodgkin - physiopathology ; Male ; Medical sciences ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - physiopathology ; Neoplasms, Second Primary ; Osteosarcoma - drug therapy ; Osteosarcoma - pathology ; Osteosarcoma - physiopathology ; Rothmund-Thomson Syndrome ; Skin involvement in other diseases. Miscellaneous. General aspects</subject><ispartof>Journal of pediatric hematology/oncology, 1998-09, Vol.20 (5), p.494-497</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-fefc649e5cfcf67d58cbe48dccd86800367ab10838d6587115621f1cd414f7723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2403807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9787328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SPURNEY, C</creatorcontrib><creatorcontrib>GORLICK, R</creatorcontrib><creatorcontrib>MEYERS, P. A</creatorcontrib><creatorcontrib>HEALEY, J. H</creatorcontrib><creatorcontrib>HUVOS, A. G</creatorcontrib><title>Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported.
A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma.
The patient was treated with anti-CD20 monoclonal antibody and is in complete remission.
This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.</description><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antigens, CD20 - immunology</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - physiopathology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Lymphoma, Non-Hodgkin - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - physiopathology</subject><subject>Neoplasms, Second Primary</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - pathology</subject><subject>Osteosarcoma - physiopathology</subject><subject>Rothmund-Thomson Syndrome</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1u1TAQhSMEKqXwCEheINjU1E4c_7CrKqBIrSqhso587XFvILGDxym6D9L3xbSXu7A8oznnjOyvaQhnHzkz6owxJjrRSsqN0czUltbD9bPmmPedpJ1U-nmtmVJUcC5eNq8Qf1aFqq6j5sgorbpWHzcP1-tURgex5NGRhAUS2uzSbE_J91S28xo9vd2mGVMkuIs-pxlOiY2eILgUvc07Ei2mZVureAd2IjFFepn83a8xfkAy7eal-u0nck6cRSAZlpTLY0SG-xH-kBRI2QKZxgLZljXD6-ZFsBPCm_190vz48vn24pJe3Xz9dnF-RV2rRaEBgpPCQO-CC1L5XrsNCO2d81pqxuov2A1nutNe9lpx3suWB-684CIo1XYnzfun3CWn3ytgGeYRHUyTjZBWHKQxpjdSVaF-ErqcEDOEYcnjXF88cDb8IzL8JzIciAyPRKr17X7HupnBH4x7BHX-bj-36OwUso1uxIOsFazTTHV_ARDclsA</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>SPURNEY, C</creator><creator>GORLICK, R</creator><creator>MEYERS, P. A</creator><creator>HEALEY, J. H</creator><creator>HUVOS, A. G</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature</title><author>SPURNEY, C ; GORLICK, R ; MEYERS, P. A ; HEALEY, J. H ; HUVOS, A. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-fefc649e5cfcf67d58cbe48dccd86800367ab10838d6587115621f1cd414f7723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antigens, CD20 - immunology</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - physiopathology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lymphoma, Non-Hodgkin - drug therapy</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Lymphoma, Non-Hodgkin - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - physiopathology</topic><topic>Neoplasms, Second Primary</topic><topic>Osteosarcoma - drug therapy</topic><topic>Osteosarcoma - pathology</topic><topic>Osteosarcoma - physiopathology</topic><topic>Rothmund-Thomson Syndrome</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SPURNEY, C</creatorcontrib><creatorcontrib>GORLICK, R</creatorcontrib><creatorcontrib>MEYERS, P. A</creatorcontrib><creatorcontrib>HEALEY, J. H</creatorcontrib><creatorcontrib>HUVOS, A. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SPURNEY, C</au><au>GORLICK, R</au><au>MEYERS, P. A</au><au>HEALEY, J. H</au><au>HUVOS, A. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>20</volume><issue>5</issue><spage>494</spage><epage>497</epage><pages>494-497</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><coden>JPHOFG</coden><abstract>Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported.
A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma.
The patient was treated with anti-CD20 monoclonal antibody and is in complete remission.
This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9787328</pmid><doi>10.1097/00043426-199809000-00018</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 1998-09, Vol.20 (5), p.494-497 |
| issn | 1077-4114 1536-3678 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69995967 |
| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antigens, CD20 - immunology Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - pathology Bone Neoplasms - physiopathology Dermatology Female Humans Infant, Newborn Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - pathology Lymphoma, Non-Hodgkin - physiopathology Male Medical sciences Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - physiopathology Neoplasms, Second Primary Osteosarcoma - drug therapy Osteosarcoma - pathology Osteosarcoma - physiopathology Rothmund-Thomson Syndrome Skin involvement in other diseases. Miscellaneous. General aspects |
| title | Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature |
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