Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients
Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 year...
Gespeichert in:
| Veröffentlicht in: | Chest 1998-10, Vol.114 (4), p.1033-1035 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1035 |
|---|---|
| container_issue | 4 |
| container_start_page | 1033 |
| container_title | Chest |
| container_volume | 114 |
| creator | Ljubić, Spomenka Metelko, Željko Car, Nikica Roglić, Gojka Dražić, Zrinka |
| description | Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 years, who had had the disease from 3 to 32 years, were included in this study. The protein excretion rate (PER) and the diffusion capacity of the lung for carbon monoxide (DLCO) were included as parameters of the severity of complications. PER was determined by the Biuret method. DLCO was measured by the single-breath method and was corrected by the measurement of alveolar volume (VA). The values of DLCO as corrected by VA (DLCO/VA) were included in the statistical evaluation of the results. The variables of age, duration of diabetes, and complication parameters were included in a multiple regression model with forward, stepwise selection to assess their value in predicting DLCO/VA. The variables were found to be significant predictors of DLCO/VA (R2 = 0.46, adjusted R2 = 0.32, p < 0.022). However, proteinuria was the only significant independent predictor of DLCO/VA. This finding indicates that both renal and pulmonary complications of diabetes share a similar microangiopathic background. |
| doi_str_mv | 10.1378/chest.114.4.1033 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69995148</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0012369216330021</els_id><sourcerecordid>35376447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-318d4f446044bb5be022118911bda99be32af32912fca172f54be0a58660d2083</originalsourceid><addsrcrecordid>eNp1kN1L7DAQxYMould990UoIr51zeSj2_gmq1cFRRF9DmmauJFusybtVf97s3eLqOBTmMzvzJk5CO0BHgOdlMd6ZmI3BmBjNgZM6RoagaCQU87oOhphDCSnhSBb6E-MzzjVIIpNtCkmgvAJHaHLe1P3unO-zbzNzpy1fVwWU7VQ2nXvmfUhFaFKfze-9W-uNplrE6kq0zmd3anOmbaLO2jDqiaa3eHdRo9_zx-ml_n17cXV9PQ61xyXXU6hrJllrMCMVRWvDCYEoBQAVa2EqAwlylIigFitYEIsZ4lRvCwKXBNc0m10tJq7CP6lT9fLuYvaNI1qje-jLIQQHNgSPPgBPvs-tGk3STBmQDjmCcIrSAcfYzBWLoKbq_AuActlwvJ_wjIlLJlcJpwk-8Pcvpqb-lMwRJr6h0NfRa0aG1SrXfzECINk_MV55p5mry4YGeeqadJQuvIctv3mfLKSmJTvP2eCjDplr02d5LqTtXe_r_0BAOOnZA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200412505</pqid></control><display><type>article</type><title>Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Ljubić, Spomenka ; Metelko, Željko ; Car, Nikica ; Roglić, Gojka ; Dražić, Zrinka</creator><creatorcontrib>Ljubić, Spomenka ; Metelko, Željko ; Car, Nikica ; Roglić, Gojka ; Dražić, Zrinka</creatorcontrib><description>Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 years, who had had the disease from 3 to 32 years, were included in this study. The protein excretion rate (PER) and the diffusion capacity of the lung for carbon monoxide (DLCO) were included as parameters of the severity of complications. PER was determined by the Biuret method. DLCO was measured by the single-breath method and was corrected by the measurement of alveolar volume (VA). The values of DLCO as corrected by VA (DLCO/VA) were included in the statistical evaluation of the results. The variables of age, duration of diabetes, and complication parameters were included in a multiple regression model with forward, stepwise selection to assess their value in predicting DLCO/VA. The variables were found to be significant predictors of DLCO/VA (R2 = 0.46, adjusted R2 = 0.32, p < 0.022). However, proteinuria was the only significant independent predictor of DLCO/VA. This finding indicates that both renal and pulmonary complications of diabetes share a similar microangiopathic background.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.114.4.1033</identifier><identifier>PMID: 9792573</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Associated diseases and complications ; Biological and medical sciences ; Carbon monoxide ; Carbon Monoxide - metabolism ; Chromatography, Ion Exchange ; Chronic Disease ; Collagen ; Connective tissue ; Diabetes ; Diabetes Complications ; diabetes mellitus ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - physiopathology ; Diabetes. Impaired glucose tolerance ; diffusion capacity of the lung for carbon monoxide corrected by alveolar volume ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Glycated Hemoglobin A - metabolism ; Hemoglobin ; Humans ; Hyperglycemia ; Lung - physiopathology ; Lung diseases ; Lung Diseases - diagnosis ; Lung Diseases - etiology ; Lung Diseases - physiopathology ; Lungs ; Male ; Medical sciences ; Middle Aged ; Photometry ; Predictive Value of Tests ; protein excretion rate ; Proteins ; Proteinuria - urine ; Pulmonary Diffusing Capacity ; Severity of Illness Index ; Variables</subject><ispartof>Chest, 1998-10, Vol.114 (4), p.1033-1035</ispartof><rights>1998 The American College of Chest Physicians</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Oct 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-318d4f446044bb5be022118911bda99be32af32912fca172f54be0a58660d2083</citedby><cites>FETCH-LOGICAL-c508t-318d4f446044bb5be022118911bda99be32af32912fca172f54be0a58660d2083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2415055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9792573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ljubić, Spomenka</creatorcontrib><creatorcontrib>Metelko, Željko</creatorcontrib><creatorcontrib>Car, Nikica</creatorcontrib><creatorcontrib>Roglić, Gojka</creatorcontrib><creatorcontrib>Dražić, Zrinka</creatorcontrib><title>Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients</title><title>Chest</title><addtitle>Chest</addtitle><description>Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 years, who had had the disease from 3 to 32 years, were included in this study. The protein excretion rate (PER) and the diffusion capacity of the lung for carbon monoxide (DLCO) were included as parameters of the severity of complications. PER was determined by the Biuret method. DLCO was measured by the single-breath method and was corrected by the measurement of alveolar volume (VA). The values of DLCO as corrected by VA (DLCO/VA) were included in the statistical evaluation of the results. The variables of age, duration of diabetes, and complication parameters were included in a multiple regression model with forward, stepwise selection to assess their value in predicting DLCO/VA. The variables were found to be significant predictors of DLCO/VA (R2 = 0.46, adjusted R2 = 0.32, p < 0.022). However, proteinuria was the only significant independent predictor of DLCO/VA. This finding indicates that both renal and pulmonary complications of diabetes share a similar microangiopathic background.</description><subject>Adult</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - metabolism</subject><subject>Chromatography, Ion Exchange</subject><subject>Chronic Disease</subject><subject>Collagen</subject><subject>Connective tissue</subject><subject>Diabetes</subject><subject>Diabetes Complications</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>diffusion capacity of the lung for carbon monoxide corrected by alveolar volume</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - physiopathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photometry</subject><subject>Predictive Value of Tests</subject><subject>protein excretion rate</subject><subject>Proteins</subject><subject>Proteinuria - urine</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Severity of Illness Index</subject><subject>Variables</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kN1L7DAQxYMould990UoIr51zeSj2_gmq1cFRRF9DmmauJFusybtVf97s3eLqOBTmMzvzJk5CO0BHgOdlMd6ZmI3BmBjNgZM6RoagaCQU87oOhphDCSnhSBb6E-MzzjVIIpNtCkmgvAJHaHLe1P3unO-zbzNzpy1fVwWU7VQ2nXvmfUhFaFKfze-9W-uNplrE6kq0zmd3anOmbaLO2jDqiaa3eHdRo9_zx-ml_n17cXV9PQ61xyXXU6hrJllrMCMVRWvDCYEoBQAVa2EqAwlylIigFitYEIsZ4lRvCwKXBNc0m10tJq7CP6lT9fLuYvaNI1qje-jLIQQHNgSPPgBPvs-tGk3STBmQDjmCcIrSAcfYzBWLoKbq_AuActlwvJ_wjIlLJlcJpwk-8Pcvpqb-lMwRJr6h0NfRa0aG1SrXfzECINk_MV55p5mry4YGeeqadJQuvIctv3mfLKSmJTvP2eCjDplr02d5LqTtXe_r_0BAOOnZA</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Ljubić, Spomenka</creator><creator>Metelko, Željko</creator><creator>Car, Nikica</creator><creator>Roglić, Gojka</creator><creator>Dražić, Zrinka</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients</title><author>Ljubić, Spomenka ; Metelko, Željko ; Car, Nikica ; Roglić, Gojka ; Dražić, Zrinka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-318d4f446044bb5be022118911bda99be32af32912fca172f54be0a58660d2083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Carbon monoxide</topic><topic>Carbon Monoxide - metabolism</topic><topic>Chromatography, Ion Exchange</topic><topic>Chronic Disease</topic><topic>Collagen</topic><topic>Connective tissue</topic><topic>Diabetes</topic><topic>Diabetes Complications</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>diffusion capacity of the lung for carbon monoxide corrected by alveolar volume</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - physiopathology</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Photometry</topic><topic>Predictive Value of Tests</topic><topic>protein excretion rate</topic><topic>Proteins</topic><topic>Proteinuria - urine</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Severity of Illness Index</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ljubić, Spomenka</creatorcontrib><creatorcontrib>Metelko, Željko</creatorcontrib><creatorcontrib>Car, Nikica</creatorcontrib><creatorcontrib>Roglić, Gojka</creatorcontrib><creatorcontrib>Dražić, Zrinka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ljubić, Spomenka</au><au>Metelko, Željko</au><au>Car, Nikica</au><au>Roglić, Gojka</au><au>Dražić, Zrinka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>114</volume><issue>4</issue><spage>1033</spage><epage>1035</epage><pages>1033-1035</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 years, who had had the disease from 3 to 32 years, were included in this study. The protein excretion rate (PER) and the diffusion capacity of the lung for carbon monoxide (DLCO) were included as parameters of the severity of complications. PER was determined by the Biuret method. DLCO was measured by the single-breath method and was corrected by the measurement of alveolar volume (VA). The values of DLCO as corrected by VA (DLCO/VA) were included in the statistical evaluation of the results. The variables of age, duration of diabetes, and complication parameters were included in a multiple regression model with forward, stepwise selection to assess their value in predicting DLCO/VA. The variables were found to be significant predictors of DLCO/VA (R2 = 0.46, adjusted R2 = 0.32, p < 0.022). However, proteinuria was the only significant independent predictor of DLCO/VA. This finding indicates that both renal and pulmonary complications of diabetes share a similar microangiopathic background.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>9792573</pmid><doi>10.1378/chest.114.4.1033</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1998-10, Vol.114 (4), p.1033-1035 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69995148 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Associated diseases and complications Biological and medical sciences Carbon monoxide Carbon Monoxide - metabolism Chromatography, Ion Exchange Chronic Disease Collagen Connective tissue Diabetes Diabetes Complications diabetes mellitus Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance diffusion capacity of the lung for carbon monoxide corrected by alveolar volume Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glycated Hemoglobin A - metabolism Hemoglobin Humans Hyperglycemia Lung - physiopathology Lung diseases Lung Diseases - diagnosis Lung Diseases - etiology Lung Diseases - physiopathology Lungs Male Medical sciences Middle Aged Photometry Predictive Value of Tests protein excretion rate Proteins Proteinuria - urine Pulmonary Diffusing Capacity Severity of Illness Index Variables |
| title | Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T19%3A45%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduction%20of%20Diffusion%20Capacity%20for%20Carbon%20Monoxide%20in%20Diabetic%20Patients&rft.jtitle=Chest&rft.au=Ljubi%C4%87,%20Spomenka&rft.date=1998-10-01&rft.volume=114&rft.issue=4&rft.spage=1033&rft.epage=1035&rft.pages=1033-1035&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.114.4.1033&rft_dat=%3Cproquest_cross%3E35376447%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=200412505&rft_id=info:pmid/9792573&rft_els_id=S0012369216330021&rfr_iscdi=true |