Detection of chromosome loss and gain induced by griseofulvin, estramustine, and vanadate in binucleated lymphocytes using FISH analysis

Cytochalasin B‐blocked binucleated human lymphocytes from a healthy male donor were used to detect micronucleus induction and other aneuploidy events (chromosome loss and gain) after treatment with griseofulvin (GF), estramustine (EM), and sodium orthovanadate (Na3VO4). A two‐color FISH was performe...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1999, Vol.34 (1), p.64-68
Hauptverfasser:	Migliore, Lucia, Zotti-Martelli, Laura, Scarpato, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Biological and medical sciences Cell Nucleus - drug effects Cell Nucleus - genetics Chemical mutagenesis chromosome loss/gain Chromosomes, Human, Pair 2 - genetics DNA Probes estramustine Estramustine - pharmacology FISH griseofulvin Griseofulvin - pharmacology human lymphocyte micronucleus assay Humans In Situ Hybridization, Fluorescence Interphase Lymphocytes - drug effects Lymphocytes - metabolism Male Medical sciences Micronuclei, Chromosome-Defective - drug effects Micronuclei, Chromosome-Defective - genetics Micronucleus Tests Toxicology vanadate Vanadates - pharmacology X Chromosome - genetics
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