Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography
Background. We compared estimates of left ventricular ejection fraction (LVEF) assessed by gated single photon emission computed tomography (SPECT), using both technetium-99m sestamibi and thallium-201, with those obtained by first-pass radionuclide angiography (FPRNA) in patients with a broad spect...
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| Veröffentlicht in: | Journal of nuclear cardiology 1999-07, Vol.6 (4), p.412-417 |
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| creator | Zuo-Xiang, HE Eduardo, Cwajg Preslar, Janice S. Mahmarian, John J. Verani, Mario S. |
| description | Background. We compared estimates of left ventricular ejection fraction (LVEF) assessed by gated single photon emission computed tomography (SPECT), using both technetium-99m sestamibi and thallium-201, with those obtained by first-pass radionuclide angiography (FPRNA) in patients with a broad spectrum of LVEF and perfusion abnormalities.
Methods. Sixty-three patients were randomly selected to undergo a dual isotope gated SPECT study (rest Tl-201 followed by adenosine Tc-99m sestamibi scintigraphy). Studies were processed by use of the Cedars quantitative gated SPECT software. FPRNA was acquired during an intravenous bolus injection of Tc-99m sestamibi and processed with a commercially available software.
Results. The estimates of LVEF were similar (
P = NS) with Tl-201 gated SPECT (54% ± 15%), Tc-99m gated SPECT (54% ± 16%), and FPRNA (54% ± 12%). There was an excellent correlation between Tc-99m and Tl-201 gated SPECT (Pearson's r = 0.92,
P |
| doi_str_mv | 10.1016/S1071-3581(99)90007-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69992559</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1071358199900077</els_id><sourcerecordid>69992559</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-cf68b998863095680738ecd747486cca4ba7f070966b6377a737f59a8f886d43</originalsourceid><addsrcrecordid>eNqFkctu1DAUhiMEou3AI4AsFqgsAvY4vpxuUDUqF6kSSJ295fgy9SiJg50U5bl4QTwzRUJsWPksvv_30fmq6hXB7wkm_MMdwYLUlElyCfAOMMaiFk-qc8LouuaMkadl_oOcVRc57wsDFOB5dUZwwwnH8rz6dW3MnLRZUPSoc35CD26YUjBzpxNye2emEAfkC3IcrJtc6sPgLGoXtNNTGfolGp1s0B0aXfJzPoB33282W_QzTPdo29VrTJAeLNqaGqBH2eVJ96ENV2gT-1GnkEvkCPuQ8lSPOmeUtC1Ns-mCdSW9C3GX9Hi_vKieed1l9_LxXVXbTzfbzZf69tvnr5vr29pQKafaeC5bACk5xcC4xIJKZ6xoRCO5MbpptfBYYOC85VQILajwDLT0JWIbuqrenmrHFH_MZWPVh2xc1-nBxTkrDgBrxqCAb_4B93FOQ1lNCdowgIYd2tgJMinmnJxXYwq9TosiWB2MqqNRddClANTRaMmvqteP5XPbO_tX6qSwAB9PgCuneAguqWyCG4yzIRV7ysbwny9-Ayj0siU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734599454</pqid></control><display><type>article</type><title>Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Alma/SFX Local Collection</source><creator>Zuo-Xiang, HE ; Eduardo, Cwajg ; Preslar, Janice S. ; Mahmarian, John J. ; Verani, Mario S.</creator><creatorcontrib>Zuo-Xiang, HE ; Eduardo, Cwajg ; Preslar, Janice S. ; Mahmarian, John J. ; Verani, Mario S.</creatorcontrib><description><![CDATA[Background. We compared estimates of left ventricular ejection fraction (LVEF) assessed by gated single photon emission computed tomography (SPECT), using both technetium-99m sestamibi and thallium-201, with those obtained by first-pass radionuclide angiography (FPRNA) in patients with a broad spectrum of LVEF and perfusion abnormalities.
Methods. Sixty-three patients were randomly selected to undergo a dual isotope gated SPECT study (rest Tl-201 followed by adenosine Tc-99m sestamibi scintigraphy). Studies were processed by use of the Cedars quantitative gated SPECT software. FPRNA was acquired during an intravenous bolus injection of Tc-99m sestamibi and processed with a commercially available software.
Results. The estimates of LVEF were similar (
P = NS) with Tl-201 gated SPECT (54% ± 15%), Tc-99m gated SPECT (54% ± 16%), and FPRNA (54% ± 12%). There was an excellent correlation between Tc-99m and Tl-201 gated SPECT (Pearson's r = 0.92,
P <.0001). There were also good linear correlations between Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.85,
P <.0001), as well as between Tl-201 gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001). In the 16 patients with LVEF < 50%, Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001) and Tl-201 gated SPECT and FPRNA (Pearson's r = 0.92,
P < .0001) correlated well.
Conclusion. LVEF can be accurately assessed by gated SPECT with either Tc-99m sestamibi or Tl-201 in properly selected patients with normal or depressed left ventricular function.]]></description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1016/S1071-3581(99)90007-7</identifier><identifier>PMID: 10461608</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Accuracy ; Adenosine ; Aged ; Female ; first-pass radionuclide angiography ; Gated SPECT ; Heart - diagnostic imaging ; Heart attacks ; Heart failure ; Humans ; LVEF ; Male ; Medical imaging ; Myocardial Ischemia - diagnostic imaging ; Random Allocation ; Stroke Volume - physiology ; Tc-99m sestamibi ; Technetium Tc 99m Sestamibi ; Thallium Radioisotopes ; Tomography, Emission-Computed, Single-Photon ; Ventricular Function, Left - physiology ; Ventriculography, First-Pass</subject><ispartof>Journal of nuclear cardiology, 1999-07, Vol.6 (4), p.412-417</ispartof><rights>1999</rights><rights>American Society of Nuclear Cardiology 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-cf68b998863095680738ecd747486cca4ba7f070966b6377a737f59a8f886d43</citedby><cites>FETCH-LOGICAL-c388t-cf68b998863095680738ecd747486cca4ba7f070966b6377a737f59a8f886d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10461608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuo-Xiang, HE</creatorcontrib><creatorcontrib>Eduardo, Cwajg</creatorcontrib><creatorcontrib>Preslar, Janice S.</creatorcontrib><creatorcontrib>Mahmarian, John J.</creatorcontrib><creatorcontrib>Verani, Mario S.</creatorcontrib><title>Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description><![CDATA[Background. We compared estimates of left ventricular ejection fraction (LVEF) assessed by gated single photon emission computed tomography (SPECT), using both technetium-99m sestamibi and thallium-201, with those obtained by first-pass radionuclide angiography (FPRNA) in patients with a broad spectrum of LVEF and perfusion abnormalities.
Methods. Sixty-three patients were randomly selected to undergo a dual isotope gated SPECT study (rest Tl-201 followed by adenosine Tc-99m sestamibi scintigraphy). Studies were processed by use of the Cedars quantitative gated SPECT software. FPRNA was acquired during an intravenous bolus injection of Tc-99m sestamibi and processed with a commercially available software.
Results. The estimates of LVEF were similar (
P = NS) with Tl-201 gated SPECT (54% ± 15%), Tc-99m gated SPECT (54% ± 16%), and FPRNA (54% ± 12%). There was an excellent correlation between Tc-99m and Tl-201 gated SPECT (Pearson's r = 0.92,
P <.0001). There were also good linear correlations between Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.85,
P <.0001), as well as between Tl-201 gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001). In the 16 patients with LVEF < 50%, Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001) and Tl-201 gated SPECT and FPRNA (Pearson's r = 0.92,
P < .0001) correlated well.
Conclusion. LVEF can be accurately assessed by gated SPECT with either Tc-99m sestamibi or Tl-201 in properly selected patients with normal or depressed left ventricular function.]]></description><subject>Accuracy</subject><subject>Adenosine</subject><subject>Aged</subject><subject>Female</subject><subject>first-pass radionuclide angiography</subject><subject>Gated SPECT</subject><subject>Heart - diagnostic imaging</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>LVEF</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Random Allocation</subject><subject>Stroke Volume - physiology</subject><subject>Tc-99m sestamibi</subject><subject>Technetium Tc 99m Sestamibi</subject><subject>Thallium Radioisotopes</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Ventricular Function, Left - physiology</subject><subject>Ventriculography, First-Pass</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkctu1DAUhiMEou3AI4AsFqgsAvY4vpxuUDUqF6kSSJ295fgy9SiJg50U5bl4QTwzRUJsWPksvv_30fmq6hXB7wkm_MMdwYLUlElyCfAOMMaiFk-qc8LouuaMkadl_oOcVRc57wsDFOB5dUZwwwnH8rz6dW3MnLRZUPSoc35CD26YUjBzpxNye2emEAfkC3IcrJtc6sPgLGoXtNNTGfolGp1s0B0aXfJzPoB33282W_QzTPdo29VrTJAeLNqaGqBH2eVJ96ENV2gT-1GnkEvkCPuQ8lSPOmeUtC1Ns-mCdSW9C3GX9Hi_vKieed1l9_LxXVXbTzfbzZf69tvnr5vr29pQKafaeC5bACk5xcC4xIJKZ6xoRCO5MbpptfBYYOC85VQILajwDLT0JWIbuqrenmrHFH_MZWPVh2xc1-nBxTkrDgBrxqCAb_4B93FOQ1lNCdowgIYd2tgJMinmnJxXYwq9TosiWB2MqqNRddClANTRaMmvqteP5XPbO_tX6qSwAB9PgCuneAguqWyCG4yzIRV7ysbwny9-Ayj0siU</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Zuo-Xiang, HE</creator><creator>Eduardo, Cwajg</creator><creator>Preslar, Janice S.</creator><creator>Mahmarian, John J.</creator><creator>Verani, Mario S.</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography</title><author>Zuo-Xiang, HE ; Eduardo, Cwajg ; Preslar, Janice S. ; Mahmarian, John J. ; Verani, Mario S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-cf68b998863095680738ecd747486cca4ba7f070966b6377a737f59a8f886d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Accuracy</topic><topic>Adenosine</topic><topic>Aged</topic><topic>Female</topic><topic>first-pass radionuclide angiography</topic><topic>Gated SPECT</topic><topic>Heart - diagnostic imaging</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Humans</topic><topic>LVEF</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Random Allocation</topic><topic>Stroke Volume - physiology</topic><topic>Tc-99m sestamibi</topic><topic>Technetium Tc 99m Sestamibi</topic><topic>Thallium Radioisotopes</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Ventricular Function, Left - physiology</topic><topic>Ventriculography, First-Pass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuo-Xiang, HE</creatorcontrib><creatorcontrib>Eduardo, Cwajg</creatorcontrib><creatorcontrib>Preslar, Janice S.</creatorcontrib><creatorcontrib>Mahmarian, John J.</creatorcontrib><creatorcontrib>Verani, Mario S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuo-Xiang, HE</au><au>Eduardo, Cwajg</au><au>Preslar, Janice S.</au><au>Mahmarian, John J.</au><au>Verani, Mario S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>6</volume><issue>4</issue><spage>412</spage><epage>417</epage><pages>412-417</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract><![CDATA[Background. We compared estimates of left ventricular ejection fraction (LVEF) assessed by gated single photon emission computed tomography (SPECT), using both technetium-99m sestamibi and thallium-201, with those obtained by first-pass radionuclide angiography (FPRNA) in patients with a broad spectrum of LVEF and perfusion abnormalities.
Methods. Sixty-three patients were randomly selected to undergo a dual isotope gated SPECT study (rest Tl-201 followed by adenosine Tc-99m sestamibi scintigraphy). Studies were processed by use of the Cedars quantitative gated SPECT software. FPRNA was acquired during an intravenous bolus injection of Tc-99m sestamibi and processed with a commercially available software.
Results. The estimates of LVEF were similar (
P = NS) with Tl-201 gated SPECT (54% ± 15%), Tc-99m gated SPECT (54% ± 16%), and FPRNA (54% ± 12%). There was an excellent correlation between Tc-99m and Tl-201 gated SPECT (Pearson's r = 0.92,
P <.0001). There were also good linear correlations between Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.85,
P <.0001), as well as between Tl-201 gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001). In the 16 patients with LVEF < 50%, Tc-99m sestamibi gated SPECT and FPRNA (Pearson's r = 0.84,
P < .0001) and Tl-201 gated SPECT and FPRNA (Pearson's r = 0.92,
P < .0001) correlated well.
Conclusion. LVEF can be accurately assessed by gated SPECT with either Tc-99m sestamibi or Tl-201 in properly selected patients with normal or depressed left ventricular function.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10461608</pmid><doi>10.1016/S1071-3581(99)90007-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of nuclear cardiology, 1999-07, Vol.6 (4), p.412-417 |
| issn | 1071-3581 1532-6551 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | Accuracy Adenosine Aged Female first-pass radionuclide angiography Gated SPECT Heart - diagnostic imaging Heart attacks Heart failure Humans LVEF Male Medical imaging Myocardial Ischemia - diagnostic imaging Random Allocation Stroke Volume - physiology Tc-99m sestamibi Technetium Tc 99m Sestamibi Thallium Radioisotopes Tomography, Emission-Computed, Single-Photon Ventricular Function, Left - physiology Ventriculography, First-Pass |
| title | Accuracy of left ventricular ejection fraction determined by gated myocardial perfusion SPECT with Tl-201 and Tc-99m sestamibi: Comparison with first-pass radionuclide angiography |
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