Cervical papanicolaou smear abnormalities in inner city Bronx adolescents : prevalence, progression, and immune modifiers
The aim of this study was to quantify the prevalence of cervical smear abnormalities in sexually active adolescents and identify the effect of immune-modifying conditions. Two hundred seventy-one females ages 13-22 years attending a clinic for sexually transmitted disease (STD) evaluation had cervic...
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| Veröffentlicht in: | Cancer 1999-08, Vol.87 (4), p.184-189 |
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| creator | EDELMAN, M FOX, A. S ALDERMAN, E. M NEAL, W SHAPIRO, A SILVER, E. J SPIGLAND, I SUHRLAND, M |
| description | The aim of this study was to quantify the prevalence of cervical smear abnormalities in sexually active adolescents and identify the effect of immune-modifying conditions.
Two hundred seventy-one females ages 13-22 years attending a clinic for sexually transmitted disease (STD) evaluation had cervical Papanicoloau (Pap) smears and completed sexual history questionnaires. Results of all follow-up Pap smears were obtained. Medical charts were available for 54 patients with cytologic follow-up and were reviewed for the presence of immune-modifying conditions. Follow-up smear results for patients with and without immune-modifying conditions were compared. Abnormality rates for all cervical smears seen in 1995 at Montefiore Medical Center were also obtained.
The smear abnormality rate for adolescents was 20. 7% (abnormal squamous cells of undetermined significance [ASCUS], 12. 2%; low grade squamous intraepithelial lesion [LGSIL], 7.7%; high grade squamous intraepithelial lesion [HGSIL], 0.7%) compared with all adult females, for whom the rate was 13.2% (ASCUS, 9.9%; LGSIL, 2.5%; HGSIL, 0.6%; carcinoma 0.2%) (P < 0.0002). Of 20 initial ASCUS patients, 6 (30%) showed LGSIL or HGSIL on follow-up. Chart review allowed the clinical immune status of 54 patients to be determined. Of 14 patients with an immune-modifying condition (9 HIV positive patients, 3 receiving oral steroids, 1 liver transplant patient receiving steroids, and 1 with intestinal lymphangiectasia), 11 (78. 6%) developed or maintained an abnormality on cytologic follow-up. Of 40 patients with no identifiable immune-modifying condition, 11 (27.5%) developed or maintained an abnormality on cytologic follow-up (P < 0.00082).
Sexually active adolescents are at higher risk of developing a significant cervical smear abnormality, especially LGSIL. Patients with an atypical Pap smear or immune-modifying condition require more attentive gynecologic monitoring. Cancer (Cancer Cytopathol) |
| doi_str_mv | 10.1002/(SICI)1097-0142(19990825)87:4<184::AID-CNCR4>3.0.CO;2-# |
| format | Article |
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Two hundred seventy-one females ages 13-22 years attending a clinic for sexually transmitted disease (STD) evaluation had cervical Papanicoloau (Pap) smears and completed sexual history questionnaires. Results of all follow-up Pap smears were obtained. Medical charts were available for 54 patients with cytologic follow-up and were reviewed for the presence of immune-modifying conditions. Follow-up smear results for patients with and without immune-modifying conditions were compared. Abnormality rates for all cervical smears seen in 1995 at Montefiore Medical Center were also obtained.
The smear abnormality rate for adolescents was 20. 7% (abnormal squamous cells of undetermined significance [ASCUS], 12. 2%; low grade squamous intraepithelial lesion [LGSIL], 7.7%; high grade squamous intraepithelial lesion [HGSIL], 0.7%) compared with all adult females, for whom the rate was 13.2% (ASCUS, 9.9%; LGSIL, 2.5%; HGSIL, 0.6%; carcinoma 0.2%) (P < 0.0002). Of 20 initial ASCUS patients, 6 (30%) showed LGSIL or HGSIL on follow-up. Chart review allowed the clinical immune status of 54 patients to be determined. Of 14 patients with an immune-modifying condition (9 HIV positive patients, 3 receiving oral steroids, 1 liver transplant patient receiving steroids, and 1 with intestinal lymphangiectasia), 11 (78. 6%) developed or maintained an abnormality on cytologic follow-up. Of 40 patients with no identifiable immune-modifying condition, 11 (27.5%) developed or maintained an abnormality on cytologic follow-up (P < 0.00082).
Sexually active adolescents are at higher risk of developing a significant cervical smear abnormality, especially LGSIL. Patients with an atypical Pap smear or immune-modifying condition require more attentive gynecologic monitoring. Cancer (Cancer Cytopathol)</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/(SICI)1097-0142(19990825)87:4<184::AID-CNCR4>3.0.CO;2-#</identifier><identifier>PMID: 10455205</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York, NY: Wiley-Liss</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Cervical Intraepithelial Neoplasia - epidemiology ; Cervical Intraepithelial Neoplasia - pathology ; Disease Progression ; Female ; Follow-Up Studies ; Genital system. Mammary gland ; Humans ; Immune System ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; New York City - epidemiology ; Papanicolaou Test ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prevalence ; Risk Factors ; Sexual Behavior ; Sexual Partners ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - pathology ; Vaginal Smears</subject><ispartof>Cancer, 1999-08, Vol.87 (4), p.184-189</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c246t-38e068923e25470dc295e6ba55e27df224a9a79e83f26b7e60afdf1d24d163e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1912100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10455205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EDELMAN, M</creatorcontrib><creatorcontrib>FOX, A. S</creatorcontrib><creatorcontrib>ALDERMAN, E. M</creatorcontrib><creatorcontrib>NEAL, W</creatorcontrib><creatorcontrib>SHAPIRO, A</creatorcontrib><creatorcontrib>SILVER, E. J</creatorcontrib><creatorcontrib>SPIGLAND, I</creatorcontrib><creatorcontrib>SUHRLAND, M</creatorcontrib><title>Cervical papanicolaou smear abnormalities in inner city Bronx adolescents : prevalence, progression, and immune modifiers</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The aim of this study was to quantify the prevalence of cervical smear abnormalities in sexually active adolescents and identify the effect of immune-modifying conditions.
Two hundred seventy-one females ages 13-22 years attending a clinic for sexually transmitted disease (STD) evaluation had cervical Papanicoloau (Pap) smears and completed sexual history questionnaires. Results of all follow-up Pap smears were obtained. Medical charts were available for 54 patients with cytologic follow-up and were reviewed for the presence of immune-modifying conditions. Follow-up smear results for patients with and without immune-modifying conditions were compared. Abnormality rates for all cervical smears seen in 1995 at Montefiore Medical Center were also obtained.
The smear abnormality rate for adolescents was 20. 7% (abnormal squamous cells of undetermined significance [ASCUS], 12. 2%; low grade squamous intraepithelial lesion [LGSIL], 7.7%; high grade squamous intraepithelial lesion [HGSIL], 0.7%) compared with all adult females, for whom the rate was 13.2% (ASCUS, 9.9%; LGSIL, 2.5%; HGSIL, 0.6%; carcinoma 0.2%) (P < 0.0002). Of 20 initial ASCUS patients, 6 (30%) showed LGSIL or HGSIL on follow-up. Chart review allowed the clinical immune status of 54 patients to be determined. Of 14 patients with an immune-modifying condition (9 HIV positive patients, 3 receiving oral steroids, 1 liver transplant patient receiving steroids, and 1 with intestinal lymphangiectasia), 11 (78. 6%) developed or maintained an abnormality on cytologic follow-up. Of 40 patients with no identifiable immune-modifying condition, 11 (27.5%) developed or maintained an abnormality on cytologic follow-up (P < 0.00082).
Sexually active adolescents are at higher risk of developing a significant cervical smear abnormality, especially LGSIL. Patients with an atypical Pap smear or immune-modifying condition require more attentive gynecologic monitoring. Cancer (Cancer Cytopathol)</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cervical Intraepithelial Neoplasia - epidemiology</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Immune System</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>New York City - epidemiology</subject><subject>Papanicolaou Test</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sexual Behavior</subject><subject>Sexual Partners</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Vaginal Smears</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkXuL1DAUxYMo7uzqV5CAIruwHfNsm1FW1voaWBzwAf53ybS3kqVNx6RdnG9v6o6rELgJnHtyOD9CXnO25IyJF6df1tX6jDNTZIwrccqNMawU-qwsVuoVL9Vqdbl-m1Wfqs_qQi7Zstq8FNnTe2Rxt3OfLBhjZaaV_H5EjmO8Ts9CaPmQHHGmtBZML8i-wnDjatvRnd1Z7-qhs8NEY482ULv1Q-ht50aHkTqfjsdAazfu6Zsw-F_UNkOHsUY_Rrqiu4A3tkNf43m6Dz8CxugGf06tb6jr-8kj7YfGtQ5DfEQetLaL-PgwT8i39---Vh-zq82HdXV5ldVC5WMmS2R5aYREoVXBmloYjfnWao2iaFohlDW2MFjKVuTbAnNm26bljVANzyVyeUKe3_qmRD8njCP0LiXuOutxmCLkqVpupJB3AeowxBiwhV1wvQ174AxmKgAzFZgbhrlh-EsFygIUJCoAiQr8oQISGFQbmH2fHAJM2x6b_1xvISTBs4PAxkSiDdbXLv7TGS7S9_I3Vy2cnw</recordid><startdate>19990825</startdate><enddate>19990825</enddate><creator>EDELMAN, M</creator><creator>FOX, A. S</creator><creator>ALDERMAN, E. M</creator><creator>NEAL, W</creator><creator>SHAPIRO, A</creator><creator>SILVER, E. J</creator><creator>SPIGLAND, I</creator><creator>SUHRLAND, M</creator><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990825</creationdate><title>Cervical papanicolaou smear abnormalities in inner city Bronx adolescents : prevalence, progression, and immune modifiers</title><author>EDELMAN, M ; FOX, A. S ; ALDERMAN, E. M ; NEAL, W ; SHAPIRO, A ; SILVER, E. J ; SPIGLAND, I ; SUHRLAND, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-38e068923e25470dc295e6ba55e27df224a9a79e83f26b7e60afdf1d24d163e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cervical Intraepithelial Neoplasia - epidemiology</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Immune System</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>New York City - epidemiology</topic><topic>Papanicolaou Test</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sexual Behavior</topic><topic>Sexual Partners</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDELMAN, M</creatorcontrib><creatorcontrib>FOX, A. S</creatorcontrib><creatorcontrib>ALDERMAN, E. M</creatorcontrib><creatorcontrib>NEAL, W</creatorcontrib><creatorcontrib>SHAPIRO, A</creatorcontrib><creatorcontrib>SILVER, E. J</creatorcontrib><creatorcontrib>SPIGLAND, I</creatorcontrib><creatorcontrib>SUHRLAND, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EDELMAN, M</au><au>FOX, A. S</au><au>ALDERMAN, E. M</au><au>NEAL, W</au><au>SHAPIRO, A</au><au>SILVER, E. J</au><au>SPIGLAND, I</au><au>SUHRLAND, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical papanicolaou smear abnormalities in inner city Bronx adolescents : prevalence, progression, and immune modifiers</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1999-08-25</date><risdate>1999</risdate><volume>87</volume><issue>4</issue><spage>184</spage><epage>189</epage><pages>184-189</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>The aim of this study was to quantify the prevalence of cervical smear abnormalities in sexually active adolescents and identify the effect of immune-modifying conditions.
Two hundred seventy-one females ages 13-22 years attending a clinic for sexually transmitted disease (STD) evaluation had cervical Papanicoloau (Pap) smears and completed sexual history questionnaires. Results of all follow-up Pap smears were obtained. Medical charts were available for 54 patients with cytologic follow-up and were reviewed for the presence of immune-modifying conditions. Follow-up smear results for patients with and without immune-modifying conditions were compared. Abnormality rates for all cervical smears seen in 1995 at Montefiore Medical Center were also obtained.
The smear abnormality rate for adolescents was 20. 7% (abnormal squamous cells of undetermined significance [ASCUS], 12. 2%; low grade squamous intraepithelial lesion [LGSIL], 7.7%; high grade squamous intraepithelial lesion [HGSIL], 0.7%) compared with all adult females, for whom the rate was 13.2% (ASCUS, 9.9%; LGSIL, 2.5%; HGSIL, 0.6%; carcinoma 0.2%) (P < 0.0002). Of 20 initial ASCUS patients, 6 (30%) showed LGSIL or HGSIL on follow-up. Chart review allowed the clinical immune status of 54 patients to be determined. Of 14 patients with an immune-modifying condition (9 HIV positive patients, 3 receiving oral steroids, 1 liver transplant patient receiving steroids, and 1 with intestinal lymphangiectasia), 11 (78. 6%) developed or maintained an abnormality on cytologic follow-up. Of 40 patients with no identifiable immune-modifying condition, 11 (27.5%) developed or maintained an abnormality on cytologic follow-up (P < 0.00082).
Sexually active adolescents are at higher risk of developing a significant cervical smear abnormality, especially LGSIL. Patients with an atypical Pap smear or immune-modifying condition require more attentive gynecologic monitoring. Cancer (Cancer Cytopathol)</abstract><cop>New York, NY</cop><pub>Wiley-Liss</pub><pmid>10455205</pmid><doi>10.1002/(SICI)1097-0142(19990825)87:4<184::AID-CNCR4>3.0.CO;2-#</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult AIDS/HIV Biological and medical sciences Cervical Intraepithelial Neoplasia - epidemiology Cervical Intraepithelial Neoplasia - pathology Disease Progression Female Follow-Up Studies Genital system. Mammary gland Humans Immune System Investigative techniques, diagnostic techniques (general aspects) Medical sciences New York City - epidemiology Papanicolaou Test Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prevalence Risk Factors Sexual Behavior Sexual Partners Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - pathology Vaginal Smears |
| title | Cervical papanicolaou smear abnormalities in inner city Bronx adolescents : prevalence, progression, and immune modifiers |
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