Rapid uptake and degradation of glycine by astroglial cells in culture: Synthesis and release of serine and lactate

Free glycine is known to have vital functions in the mammalian brain, where it serves mainly as both neurotransmitter and neuromodulator. Despite its importance, little is known about the metabolic pathways of glycine synthesis and degradation in the central nervous system. In this study, the pathwa...

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Veröffentlicht in:	Glia 1999-09, Vol.27 (3), p.239-248
Hauptverfasser:	Verleysdonk, Stephan, Martin, Heiko, Willker, Wieland, Leibfritz, Dieter, Hamprecht, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes - metabolism astroglial cells Biological and medical sciences Biological Transport Carbon Isotopes Carbon Radioisotopes Cells, Cultured Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology glycine Glycine - metabolism Isolated neuron and nerve. Neuroglia Kinetics lactate Lactates - metabolism lactic acid Magnetic Resonance Spectroscopy Nitrogen Isotopes Rats Rats, Wistar serine Serine - metabolism Vertebrates: nervous system and sense organs
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