Impaired thymopoietic potential of immature CD3–CD4+CD8– T cell precursors from SIV-infected rhesus monkeys
Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey–mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicate...
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| Veröffentlicht in: | International immunology 1999-09, Vol.11 (9), p.1509-1518 |
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| container_title | International immunology |
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| creator | Neben, Kai Heidbreder, Marc Müller, Justus Marxer, Anke Petry, Harald Didier, Andrea Schimpl, Anneliese Hünig, Thomas Kerkau, Thomas |
| description | Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey–mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. The data suggest that in patients infected with HIV, T cell maturation and thus replenishment of peripheral pools may be compromised as a result of intrathymic infection or circulating viral gp120. |
| doi_str_mv | 10.1093/intimm/11.9.1509 |
| format | Article |
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We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. 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Immunol</addtitle><description>Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey–mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. The data suggest that in patients infected with HIV, T cell maturation and thus replenishment of peripheral pools may be compromised as a result of intrathymic infection or circulating viral gp120.</description><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antigens, CD - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Separation - methods</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>FTOC fetal thymus organ culture</subject><subject>HIV Envelope Protein gp120 - pharmacology</subject><subject>Immunity, Cellular</subject><subject>immunodeficiency viruses</subject><subject>Lymphocyte Count</subject><subject>Macaca mulatta</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Polymerase Chain Reaction</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Immunodeficiency Virus</subject><subject>T cell development</subject><subject>T-Lymphocyte Subsets - cytology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - virology</subject><subject>thymus</subject><subject>Thymus Gland - cytology</subject><issn>0953-8178</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhi0EotvCnROyOHCpsp1ZJ3F8pFloV6zKgQUhLpY3HatuN3GwE4m98Q68IU9Sr1KhqvJhLPmbf37Pz9gbhDmCEmeuG1zbniHO1RwLUM_YDPMSsoWQ8jmbgSpEVqGsjthxjLcAIBZKvGRHCHmZo1zMmF-1vXGBrvlws2997x0NruG9Hyhpmx33lqcRZhgD8Xop_v35Wy_z03pZpRvf8IZ2O94HasYQfYjcBt_yr6vvmessNUPSDTcUx8hb393RPr5iL6zZRXr9UE_Yt08fN_Vltv5ysao_rLNGlGLICAkaC3khhMLCwLaosERjcSspB6gsFUiVTafBqgI0uUjfB6W2OTa2WogT9n7S7YP_NVIcdOviwazpyI9Rl0opkLJM4Lsn4K0fQ5e8aVQFgAShEgQT1AQfYyCr--BaE_YaQR-S0FMSGlErfUgitbx90B23LV0_aphWn4BsAlwc6Pf_dxPudCmFLPTlj5_6aqM-y6vztV6Ke8Pklcw</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Neben, Kai</creator><creator>Heidbreder, Marc</creator><creator>Müller, Justus</creator><creator>Marxer, Anke</creator><creator>Petry, Harald</creator><creator>Didier, Andrea</creator><creator>Schimpl, Anneliese</creator><creator>Hünig, Thomas</creator><creator>Kerkau, Thomas</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990901</creationdate><title>Impaired thymopoietic potential of immature CD3–CD4+CD8– T cell precursors from SIV-infected rhesus monkeys</title><author>Neben, Kai ; 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Immunol</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>11</volume><issue>9</issue><spage>1509</spage><epage>1518</epage><pages>1509-1518</pages><issn>0953-8178</issn><eissn>1460-2377</eissn><abstract>Immature thymocyte subpopulations were examined for their capacity to differentiate in a newly developed xenogeneic monkey–mouse fetal thymus organ culture (FTOC) system. We provide evidence for impaired precursor function of CD3–CD4+CD8– thymocytes after in vivo infection with SIVmac251 as indicated by a reduced cell number per FTOC and a lower percentage of thymocytes with more mature phenotypes. Addition of recombinant SIV glycoprotein 120 (rgp120) also resulted in a dose-dependent impairment of T cell maturation in FTOC. 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| ispartof | International immunology, 1999-09, Vol.11 (9), p.1509-1518 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AIDS AIDS/HIV Animals Antigens, CD - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cell Separation - methods Cells, Cultured Dose-Response Relationship, Immunologic FTOC fetal thymus organ culture HIV Envelope Protein gp120 - pharmacology Immunity, Cellular immunodeficiency viruses Lymphocyte Count Macaca mulatta Mice Mice, Inbred BALB C Polymerase Chain Reaction Simian Acquired Immunodeficiency Syndrome - immunology Simian Immunodeficiency Virus T cell development T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology thymus Thymus Gland - cytology |
| title | Impaired thymopoietic potential of immature CD3–CD4+CD8– T cell precursors from SIV-infected rhesus monkeys |
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