Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction

We have developed a quantitative method for methylation analysis of the p16 gene based on real-time methylation-specific PCR (MSP). Real-time MSP is sensitive enough to detect down to 10 genome equivalents of the methylated p16 sequence. Application of real-time MSP to DNA from tumor-derived cell li...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-08, Vol.59 (16), p.3899-3903
Hauptverfasser:	DENNIS LO, Y. M, WONG, I. H. N, JUN ZHANG, TEIN, M. S. C, NG, M. H. L, HJELM, N. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA Methylation Genes, p16 Host-tumor relations. Immunology. Biological markers Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction - methods Sensitivity and Specificity Time Factors Tumors
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