Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice

Serum IgM has been shown to participate in the control of IgG autoreactivity in healthy subjects. We have recently shown that an immunoglobulin preparation of pooled normal human IgM (IVIgM) contains anti‐idiotypic antibodies against disease‐associated IgG autoantibodies in autoimmune patients and p...

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Veröffentlicht in:	European journal of immunology 1999-08, Vol.29 (8), p.2436-2442
Hauptverfasser:	Vassilev, Tchavdar, Yamamoto, Maria, Aissaoui, Abderrahim, Bonnin, Emmanuelle, Berrih‐Aknin, Sonia, Kazatchkine, Michel D., Kaveri, Srinivas V.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine receptors Animals Autoantibodies - blood Autoimmunity Disease Models, Animal Female Humans IgM Immunoglobulin G - blood Immunoglobulin M - administration & dosage Immunoglobulin M - isolation & purification Immunoglobulin M - therapeutic use Immunoglobulins, Intravenous - therapeutic use Immunomodulation Immunosuppression Mice Mice, SCID Motor Endplate - immunology Motor Endplate - metabolism Myasthenia gravis Myasthenia Gravis - etiology Myasthenia Gravis - immunology Myasthenia Gravis - therapy Rats Receptors, Cholinergic - immunology Receptors, Cholinergic - metabolism SCID
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