A novel mechanism for upregulation of the Escherichia coli K‐12 hmp (flavohaemoglobin) gene by the ‘NO releaser’, S‐nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the glyA‐hmp intergenic region

The flavohaemoglobin gene, hmp, of Escherichia coli is upregulated by nitric oxide (NO) in a SoxRS‐independent manner. We now show that hmp expression is also upregulated by S‐nitrosoglutathione (GSNO, widely used as an NO releaser) and sodium nitroprusside (SNP, which is a NO+ donor). Elevated homo...

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Veröffentlicht in:	Molecular microbiology 1998-08, Vol.29 (4), p.1101-1112
Hauptverfasser:	Membrillo‐Hernández, Jorge, Coopamah, Malini D., Channa, Asif, Hughes, Martin N., Poole, Robert K.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Binding Sites - genetics Dihydropteridine Reductase DNA Primers - genetics DNA, Bacterial - genetics DNA, Bacterial - metabolism Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins Gene Expression Regulation, Bacterial - drug effects Genes, Bacterial Glutathione - analogs & derivatives Glutathione - pharmacology Glycine Hydroxymethyltransferase - genetics Hemeproteins - genetics Homocysteine - metabolism Methyltransferases Models, Biological Molecular Sequence Data Mutation NADH, NADPH Oxidoreductases Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Nitroso Compounds - pharmacology S-Nitrosoglutathione Trans-Activators - genetics Trans-Activators - metabolism Up-Regulation - drug effects
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