Immunity obtained by gene-gun inoculation of a rotavirus DNA vaccine to the abdominal epidermis or anorectal epithelium

We have previously shown that gene-gun delivery of murine rotavirus DNA vaccines to the epidermis induced protection against rotavirus challenge in mice. In this study, we used a rotavirus group antigen (VP6)-specific DNA vaccine to compare epidermal immunization with immunization to the anorectal e...

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Veröffentlicht in:	Vaccine 1999-08, Vol.17 (23), p.3171-3176
Hauptverfasser:	Chen, Shing C, Fynan, Ellen F, Greenberg, Harry B, Herrmann, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen AIDS/HIV Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood Antibody Specificity Antigens, Viral - immunology Biolistics Biological and medical sciences Epidermis Epithelium Female Fundamental and applied biological sciences. Psychology Intestinal Mucosa - immunology Lymphocyte Activation - immunology Mice Mice, Inbred BALB C Microbiology Mucosal Plasmid DNA immunization Rectum Rotavirus Rotavirus - genetics Rotavirus - immunology Rotavirus Infections - prevention & control Th1 Cells - immunology Th2 Cells - immunology Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Virology
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