Chimeric Influenza Virus Replicating Predominantly in the Murine Upper Respiratory Tract Induces Local Immune Responses against Human Immunodeficiency Virus Type 1 in the Genital Tract

Previously, a mucosal model of immunization against human immunodeficiency virus type 1 (HIV-1) was established by using influenza virus as a vector for the neutralizing gp41 epitope ELDKWA. Whether replication of this chimeric influenza virus in the upper respiratory tract of mice is sufficient for...

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Veröffentlicht in:	The Journal of infectious diseases 1998-11, Vol.178 (5), p.1359-1368
Hauptverfasser:	Ferko, Boris, Katinger, Dietmar, Grassauer, Andreas, Egorov, Andrej, Romanova, Julia, Niebler, Brigitte, Katinger, Hermann, Muster, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal AIDS Vaccines - immunology AIDS/HIV Anesthesia Animals Antibodies Antibodies, Monoclonal - metabolism B lymphocytes Chimera Enzyme-Linked Immunosorbent Assay Female Genetic Vectors HIV 1 HIV Antibodies - biosynthesis HIV Antibodies - immunology HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - immunology HIV-1 - genetics HIV-1 - immunology Humans Immunity, Mucosal Immunization Influenza A virus - genetics Influenza A virus - immunology Influenza A virus - physiology Intestinal Mucosa - immunology Intestinal Mucosa - virology Lung - immunology Lung - virology Lymphocytes Mice Mice, Inbred BALB C Mucous Membrane - immunology Mucous Membrane - virology Nasal Mucosa - immunology Nasal Mucosa - virology Orthomyxoviridae Peptide Fragments - immunology Reassortant Viruses - genetics Reassortant Viruses - immunology Vaccination Vagina - immunology Vagina - metabolism Vagina - virology Virus Replication Viruses
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