Early progenitor cells from human mobilized peripheral blood express low levels of the flt3 receptor, but exhibit various biological responses to flt3‐L

The biological effects of flt3‐L, and the expression of its tyrosine kinase receptor (flt3, CD135) were investigated on the immature subsets of human circulating peripheral blood progenitors obtained from cancer patients or normal volunteer donors, after mobilization with rhG‐CSF or chemotherapy. fl...

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Veröffentlicht in:	British journal of haematology 1999-08, Vol.106 (2), p.357-367
Hauptverfasser:	Aurran‐Schleinitz, Thérèse, Imbert, Anne‐Marie, Humeau, Laurent, Bardin, Florence, Charbord, Pierre, Chabannon, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Antigens, CD Antigens, CD34 Antigens, Differentiation Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell Division - physiology Cell physiology Cell Survival Flow Cytometry flt3 Fundamental and applied biological sciences. Psychology haemopoiesis Hematology Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Membrane Glycoproteins Membrane Proteins - metabolism Molecular and cellular biology NAD+ Nucleosidase peripheral blood progenitors Receptor Protein-Tyrosine Kinases - metabolism stem cells Tumor Cells, Cultured tyrosine kinase receptors
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