Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
The vertebrate Unc5 genes, like their Caenorhabditis elegans counterpart, define a family of putative netrin receptors. One member of this family, Unc5h3, has been shown to have an important role during cell migration in the developing murine cerebellum. Mice homozygous for mutations in Unc5h3 are a...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1998-09, Vol.52 (2), p.205-208 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | ACKERMAN, S. L KNOWLES, B. B |
| description | The vertebrate Unc5 genes, like their Caenorhabditis elegans counterpart, define a family of putative netrin receptors. One member of this family, Unc5h3, has been shown to have an important role during cell migration in the developing murine cerebellum. Mice homozygous for mutations in Unc5h3 are ataxic and have cerebellar hypoplasia and laminar structure defects. In addition, these mice have ectopic granule and Purkinje cells in the midbrain and brainstem. We have identified the human homologue of this gene, UNC5C, and shown it to have a restricted expression pattern in adult human tissues. By radiation hybrid analysis, we have determined that UNC5C localizes to chromosome 4q21-q23 between markers D4S1557 and D4S836 and is closely linked to the Parkinson disease gene. |
| doi_str_mv | 10.1006/geno.1998.5425 |
| format | Article |
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Genome ; Helminth Proteins - genetics ; Humans ; Kidney - chemistry ; Lung - chemistry ; Membrane Proteins - genetics ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Netrin Receptors ; Receptors, Cell Surface - genetics ; Receptors, Growth Factor - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Tissue Distribution</subject><ispartof>Genomics (San Diego, Calif.), 1998-09, Vol.52 (2), p.205-208</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2438580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9782087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ACKERMAN, S. 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B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-46cecefaadb1cc31264d1566716ef7d2c17990f8fea2b0f8cf8ade5e3172c8f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Brain - metabolism</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans Proteins</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 4 - genetics</topic><topic>Cloning, Molecular</topic><topic>DNA, Complementary - chemistry</topic><topic>DNA, Complementary - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genes - genetics</topic><topic>Genes. Genome</topic><topic>Helminth Proteins - genetics</topic><topic>Humans</topic><topic>Kidney - chemistry</topic><topic>Lung - chemistry</topic><topic>Membrane Proteins - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Netrin Receptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Growth Factor - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ACKERMAN, S. L</creatorcontrib><creatorcontrib>KNOWLES, B. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>52</volume><issue>2</issue><spage>205</spage><epage>208</epage><pages>205-208</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The vertebrate Unc5 genes, like their Caenorhabditis elegans counterpart, define a family of putative netrin receptors. One member of this family, Unc5h3, has been shown to have an important role during cell migration in the developing murine cerebellum. Mice homozygous for mutations in Unc5h3 are ataxic and have cerebellar hypoplasia and laminar structure defects. In addition, these mice have ectopic granule and Purkinje cells in the midbrain and brainstem. We have identified the human homologue of this gene, UNC5C, and shown it to have a restricted expression pattern in adult human tissues. By radiation hybrid analysis, we have determined that UNC5C localizes to chromosome 4q21-q23 between markers D4S1557 and D4S836 and is closely linked to the Parkinson disease gene.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>9782087</pmid><doi>10.1006/geno.1998.5425</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Amino Acid Sequence Biological and medical sciences Blotting, Northern Brain - metabolism Caenorhabditis elegans Caenorhabditis elegans Proteins Chromosome Mapping Chromosomes, Human, Pair 4 - genetics Cloning, Molecular DNA, Complementary - chemistry DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Gene Expression Genes - genetics Genes. Genome Helminth Proteins - genetics Humans Kidney - chemistry Lung - chemistry Membrane Proteins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Netrin Receptors Receptors, Cell Surface - genetics Receptors, Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution |
| title | Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23 |
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