Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5389), p.754-759 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 282 |
| creator | Stephens, Richard S. Kalman, Sue Lammel, Claudia Fan, Jun Marathe, Rekha Aravind, L. Mitchell, Wayne Olinger, Lynn Tatusov, Roman L. Zhao, Qixun Koonin, Eugene V. Davis, Ronald W. |
| description | Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism. |
| doi_str_mv | 10.1126/science.282.5389.754 |
| format | Article |
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Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.282.5389.754</identifier><identifier>PMID: 9784136</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adenosine triphosphatases ; Aerobiosis ; Amino Acid Sequence ; Amino acids ; Amino Acids - biosynthesis ; Bacteria ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacteriology ; Biological and medical sciences ; Biological Evolution ; Biosynthesis ; Chlamydia ; Chlamydia trachomatis ; Chlamydia trachomatis - classification ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - metabolism ; Chlamydia trachomatis - physiology ; DNA Repair ; Energy Metabolism ; Enzymes ; Enzymes - chemistry ; Enzymes - genetics ; Fundamental and applied biological sciences. Psychology ; Genes ; Genetics ; Genome, Bacterial ; Genomes ; Humans ; Lipids - biosynthesis ; Microbiology ; Molecular Sequence Data ; Observations ; Operons ; Peptidoglycan - biosynthesis ; Peptidoglycan - genetics ; Phylogenetics ; Phylogeny ; Protein Biosynthesis ; Recombination, Genetic ; Sequence Analysis, DNA ; Space life sciences ; Transcription, Genetic ; Transformation, Bacterial ; Virulence</subject><ispartof>Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5389), p.754-759</ispartof><rights>Copyright 1998 American Association for the Advancement of Science</rights><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c774t-a8d24b87ed8a40da0102afaa36024f928ff571bd0590f2b064bea79251a960373</citedby><cites>FETCH-LOGICAL-c774t-a8d24b87ed8a40da0102afaa36024f928ff571bd0590f2b064bea79251a960373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2899270$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2899270$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1583674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9784136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stephens, Richard S.</creatorcontrib><creatorcontrib>Kalman, Sue</creatorcontrib><creatorcontrib>Lammel, Claudia</creatorcontrib><creatorcontrib>Fan, Jun</creatorcontrib><creatorcontrib>Marathe, Rekha</creatorcontrib><creatorcontrib>Aravind, L.</creatorcontrib><creatorcontrib>Mitchell, Wayne</creatorcontrib><creatorcontrib>Olinger, Lynn</creatorcontrib><creatorcontrib>Tatusov, Roman L.</creatorcontrib><creatorcontrib>Zhao, Qixun</creatorcontrib><creatorcontrib>Koonin, Eugene V.</creatorcontrib><creatorcontrib>Davis, Ronald W.</creatorcontrib><title>Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.</description><subject>Adenosine triphosphatases</subject><subject>Aerobiosis</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Amino Acids - biosynthesis</subject><subject>Bacteria</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Biosynthesis</subject><subject>Chlamydia</subject><subject>Chlamydia trachomatis</subject><subject>Chlamydia trachomatis - classification</subject><subject>Chlamydia trachomatis - genetics</subject><subject>Chlamydia trachomatis - metabolism</subject><subject>Chlamydia trachomatis - physiology</subject><subject>DNA Repair</subject><subject>Energy Metabolism</subject><subject>Enzymes</subject><subject>Enzymes - chemistry</subject><subject>Enzymes - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Humans</subject><subject>Lipids - biosynthesis</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Observations</subject><subject>Operons</subject><subject>Peptidoglycan - biosynthesis</subject><subject>Peptidoglycan - genetics</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Protein Biosynthesis</subject><subject>Recombination, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Space life sciences</subject><subject>Transcription, Genetic</subject><subject>Transformation, Bacterial</subject><subject>Virulence</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklFr2zAUhc3Y6NJu_6ADP4zRhzqTJcuS9taFLQ2EZdCtr-LavkpcZKu1bFj__WRiOgKBBT0IdD4d6XBPFF2mZJ6mNP_syxrbEudU0jlnUs0Fz15Fs5QonihK2OtoRgjLE0kEfxude_9ASNAUO4vOlJBZyvJZdL_E1jUY3-HTMLrFzsTQxpvC1lvoMV61fQclWjtY6OKf0O_cFtuRuh0aaP2XeLGz0DxXNcQjuXMN9LV_F70xYD2-n_aL6Pf3b78Wt8l6s1wtbtZJKUTWJyArmhVSYCUhIxWQlFAwACwnNDOKSmO4SIuKcEUMLUieFQhCUZ6CygkT7CL6tPd97FwI4Hvd1H78LrToBq9zpWQ2Rv0fmOacqPBoAK_34BYs6ro1bowVMmMH1rVo6nB8wxmXMlOjb3IED6vCpi6P8VcHfEB6_NNvYfBer-5-nIxu7k9Gvy5PReVyfYBeH0NLZy1uUYdBLjYHeLbHy85536HRj13dQPesU6LHxuqpsTo0Vo-N1aGx4dqHaTJD0WD1cmmqaNA_Tjr4EqzpoC1r_8-bS5aL0eZyjz343nUvMpVKUUHYX-Jq-bo</recordid><startdate>19981023</startdate><enddate>19981023</enddate><creator>Stephens, Richard S.</creator><creator>Kalman, Sue</creator><creator>Lammel, Claudia</creator><creator>Fan, Jun</creator><creator>Marathe, Rekha</creator><creator>Aravind, L.</creator><creator>Mitchell, Wayne</creator><creator>Olinger, Lynn</creator><creator>Tatusov, Roman L.</creator><creator>Zhao, Qixun</creator><creator>Koonin, Eugene V.</creator><creator>Davis, Ronald W.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19981023</creationdate><title>Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis</title><author>Stephens, Richard S. ; Kalman, Sue ; Lammel, Claudia ; Fan, Jun ; Marathe, Rekha ; Aravind, L. ; Mitchell, Wayne ; Olinger, Lynn ; Tatusov, Roman L. ; Zhao, Qixun ; Koonin, Eugene V. ; Davis, Ronald W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c774t-a8d24b87ed8a40da0102afaa36024f928ff571bd0590f2b064bea79251a960373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adenosine triphosphatases</topic><topic>Aerobiosis</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Amino Acids - biosynthesis</topic><topic>Bacteria</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Biosynthesis</topic><topic>Chlamydia</topic><topic>Chlamydia trachomatis</topic><topic>Chlamydia trachomatis - classification</topic><topic>Chlamydia trachomatis - genetics</topic><topic>Chlamydia trachomatis - metabolism</topic><topic>Chlamydia trachomatis - physiology</topic><topic>DNA Repair</topic><topic>Energy Metabolism</topic><topic>Enzymes</topic><topic>Enzymes - chemistry</topic><topic>Enzymes - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genome, Bacterial</topic><topic>Genomes</topic><topic>Humans</topic><topic>Lipids - biosynthesis</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Observations</topic><topic>Operons</topic><topic>Peptidoglycan - biosynthesis</topic><topic>Peptidoglycan - genetics</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Protein Biosynthesis</topic><topic>Recombination, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Space life sciences</topic><topic>Transcription, Genetic</topic><topic>Transformation, Bacterial</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stephens, Richard S.</creatorcontrib><creatorcontrib>Kalman, Sue</creatorcontrib><creatorcontrib>Lammel, Claudia</creatorcontrib><creatorcontrib>Fan, Jun</creatorcontrib><creatorcontrib>Marathe, Rekha</creatorcontrib><creatorcontrib>Aravind, L.</creatorcontrib><creatorcontrib>Mitchell, Wayne</creatorcontrib><creatorcontrib>Olinger, Lynn</creatorcontrib><creatorcontrib>Tatusov, Roman L.</creatorcontrib><creatorcontrib>Zhao, Qixun</creatorcontrib><creatorcontrib>Koonin, Eugene V.</creatorcontrib><creatorcontrib>Davis, Ronald W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stephens, Richard S.</au><au>Kalman, Sue</au><au>Lammel, Claudia</au><au>Fan, Jun</au><au>Marathe, Rekha</au><au>Aravind, L.</au><au>Mitchell, Wayne</au><au>Olinger, Lynn</au><au>Tatusov, Roman L.</au><au>Zhao, Qixun</au><au>Koonin, Eugene V.</au><au>Davis, Ronald W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1998-10-23</date><risdate>1998</risdate><volume>282</volume><issue>5389</issue><spage>754</spage><epage>759</epage><pages>754-759</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9784136</pmid><doi>10.1126/science.282.5389.754</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5389), p.754-759 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69984841 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adenosine triphosphatases Aerobiosis Amino Acid Sequence Amino acids Amino Acids - biosynthesis Bacteria Bacterial Outer Membrane Proteins - genetics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacteriology Biological and medical sciences Biological Evolution Biosynthesis Chlamydia Chlamydia trachomatis Chlamydia trachomatis - classification Chlamydia trachomatis - genetics Chlamydia trachomatis - metabolism Chlamydia trachomatis - physiology DNA Repair Energy Metabolism Enzymes Enzymes - chemistry Enzymes - genetics Fundamental and applied biological sciences. Psychology Genes Genetics Genome, Bacterial Genomes Humans Lipids - biosynthesis Microbiology Molecular Sequence Data Observations Operons Peptidoglycan - biosynthesis Peptidoglycan - genetics Phylogenetics Phylogeny Protein Biosynthesis Recombination, Genetic Sequence Analysis, DNA Space life sciences Transcription, Genetic Transformation, Bacterial Virulence |
| title | Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis |
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