An anti-inflammatory role for glucocorticoids in the ovaries?
Roles of glucocorticoids in the direct regulation of ovarian function are poorly understood. This opinion paper highlights: (1) the inflammatory nature of the ovulatory process; (2) the contributions of cytokines and prostaglandins (hence inflammation) to ovulation; (3) the development-related patte...
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| Veröffentlicht in: | Journal of reproductive immunology 1998-08, Vol.39 (1), p.21-27 |
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| container_title | Journal of reproductive immunology |
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| creator | Hillier, S.G Tetsuka, M |
| description | Roles of glucocorticoids in the direct regulation of ovarian function are poorly understood. This opinion paper highlights: (1) the inflammatory nature of the ovulatory process; (2) the contributions of cytokines and prostaglandins (hence inflammation) to ovulation; (3) the development-related pattern of 11
β-hydroxysteroid (11
βHSD) isoform expression (hence glucocorticoid metabolism) that occurs in ovarian follicles; and (4) the attribution of general anti-inflammatory properties of glucocorticoids to their interference with prostaglandin synthesis. We interpret the evidence cited to hypothesise that corticosteroids serve an anti-inflammatory role during ovulation, thereby promoting rapid healing of the wound left by follicular rupture. Other possible levels of glucocorticoid action in the ovaries are also considered. |
| doi_str_mv | 10.1016/S0165-0378(98)00011-4 |
| format | Article |
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β-hydroxysteroid (11
βHSD) isoform expression (hence glucocorticoid metabolism) that occurs in ovarian follicles; and (4) the attribution of general anti-inflammatory properties of glucocorticoids to their interference with prostaglandin synthesis. We interpret the evidence cited to hypothesise that corticosteroids serve an anti-inflammatory role during ovulation, thereby promoting rapid healing of the wound left by follicular rupture. Other possible levels of glucocorticoid action in the ovaries are also considered.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/S0165-0378(98)00011-4</identifier><identifier>PMID: 9786451</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Corticosteroids ; Female ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - physiology ; Gonadotrophins ; Humans ; Hydrocortisone - physiology ; Inflammation ; Inflammation - prevention & control ; Mammalian female genital system ; Morphology. Physiology ; Oogenesis ; Ovary ; Ovary - physiology ; Ovulation ; Prostaglandins ; Vertebrates: reproduction</subject><ispartof>Journal of reproductive immunology, 1998-08, Vol.39 (1), p.21-27</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-4bc84ec3ef23dad6637c25e5ab6781ed0bbc0c9df072358f0ab514b498f27a0f3</citedby><cites>FETCH-LOGICAL-c486t-4bc84ec3ef23dad6637c25e5ab6781ed0bbc0c9df072358f0ab514b498f27a0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-0378(98)00011-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23929,23930,25139,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1588914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9786451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillier, S.G</creatorcontrib><creatorcontrib>Tetsuka, M</creatorcontrib><title>An anti-inflammatory role for glucocorticoids in the ovaries?</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Roles of glucocorticoids in the direct regulation of ovarian function are poorly understood. This opinion paper highlights: (1) the inflammatory nature of the ovulatory process; (2) the contributions of cytokines and prostaglandins (hence inflammation) to ovulation; (3) the development-related pattern of 11
β-hydroxysteroid (11
βHSD) isoform expression (hence glucocorticoid metabolism) that occurs in ovarian follicles; and (4) the attribution of general anti-inflammatory properties of glucocorticoids to their interference with prostaglandin synthesis. We interpret the evidence cited to hypothesise that corticosteroids serve an anti-inflammatory role during ovulation, thereby promoting rapid healing of the wound left by follicular rupture. Other possible levels of glucocorticoid action in the ovaries are also considered.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Corticosteroids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - physiology</subject><subject>Gonadotrophins</subject><subject>Humans</subject><subject>Hydrocortisone - physiology</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Mammalian female genital system</subject><subject>Morphology. Physiology</subject><subject>Oogenesis</subject><subject>Ovary</subject><subject>Ovary - physiology</subject><subject>Ovulation</subject><subject>Prostaglandins</subject><subject>Vertebrates: reproduction</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKEHET1Uk-b7IMsifoHgQT2HNJ1opG3WpCv47-26y3r0MnOYZ94ZHoSOCb4gmIjL57HwElOpzrQ6xxgTUrItNCFKVqUUmG6jyQbZQ_s5f4yMxJrsol0tlWCcTNDVrC9sP4Qy9L61XWeHmL6LFFsofEzFW7tw0cU0BBdDk4vQF8M7FPHLpgB5eoh2vG0zHK37AXq9vXm5vi8fn-4ermePpWNKDCWrnWLgKPiKNrYRgkpXceC2FlIRaHBdO-x047GsKFce25oTVjOtfCUt9vQAna5y5yl-LiAPpgvZQdvaHuIiG6G1ohXH_4JEME0ZpSPIV6BLMecE3sxT6Gz6NgSbpV_z69cs5RmtzK9fw8a94_WBRd1Bs9laCx3nJ-u5zc62PtnehfwXzpXSZBkzXWEwWvsKkEx2AXoHTUjgBtPE8M8jPzWelp0</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Hillier, S.G</creator><creator>Tetsuka, M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>An anti-inflammatory role for glucocorticoids in the ovaries?</title><author>Hillier, S.G ; Tetsuka, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-4bc84ec3ef23dad6637c25e5ab6781ed0bbc0c9df072358f0ab514b498f27a0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Corticosteroids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - physiology</topic><topic>Gonadotrophins</topic><topic>Humans</topic><topic>Hydrocortisone - physiology</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>Mammalian female genital system</topic><topic>Morphology. Physiology</topic><topic>Oogenesis</topic><topic>Ovary</topic><topic>Ovary - physiology</topic><topic>Ovulation</topic><topic>Prostaglandins</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillier, S.G</creatorcontrib><creatorcontrib>Tetsuka, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillier, S.G</au><au>Tetsuka, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An anti-inflammatory role for glucocorticoids in the ovaries?</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>39</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>Roles of glucocorticoids in the direct regulation of ovarian function are poorly understood. This opinion paper highlights: (1) the inflammatory nature of the ovulatory process; (2) the contributions of cytokines and prostaglandins (hence inflammation) to ovulation; (3) the development-related pattern of 11
β-hydroxysteroid (11
βHSD) isoform expression (hence glucocorticoid metabolism) that occurs in ovarian follicles; and (4) the attribution of general anti-inflammatory properties of glucocorticoids to their interference with prostaglandin synthesis. We interpret the evidence cited to hypothesise that corticosteroids serve an anti-inflammatory role during ovulation, thereby promoting rapid healing of the wound left by follicular rupture. Other possible levels of glucocorticoid action in the ovaries are also considered.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9786451</pmid><doi>10.1016/S0165-0378(98)00011-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of reproductive immunology, 1998-08, Vol.39 (1), p.21-27 |
| issn | 0165-0378 1872-7603 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Corticosteroids Female Fundamental and applied biological sciences. Psychology Glucocorticoids - physiology Gonadotrophins Humans Hydrocortisone - physiology Inflammation Inflammation - prevention & control Mammalian female genital system Morphology. Physiology Oogenesis Ovary Ovary - physiology Ovulation Prostaglandins Vertebrates: reproduction |
| title | An anti-inflammatory role for glucocorticoids in the ovaries? |
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