Inhibition by Alkylamines of NADPH Oxidase Through Blocking the Assembly of Enzyme Components

Alkylamines inhibit NADPH oxidase both in intact neutrophils and in a cell-free system. The aim of this study was to examine the mechanism underlying this inhibitory effect. Among alkylamines with different chain lengths, the C12 compound (laurylamine) showed the greatest inhibitory effect on the ce...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Japanese Journal of Pharmacology 1999, Vol.80(3), pp.237-242
Hauptverfasser:	Sawai, Tohru, Asada, Makoto, Nishizawa, Yukio, Nunoi, Hiroyuki, Katayama, Kouichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylamine Amines - pharmacology Arachidonic acid Arachidonic Acid - pharmacology Cell-Free System - drug effects Cell-Free System - enzymology Dose-Response Relationship, Drug Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology HL-60 Cells Humans NADPH oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Neutrophil Translocation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!