Evidence for the Involvement of JAK/STAT Pathway in the Signaling Mechanism of Interleukin-17

Interleukin-17 is a T-cell-derived pro-inflammatory cytokine, exhibiting multiple biological activities in a variety of cells and believed to fine tune all general phases of hematopoietic response. However, the signaling mechanism of this novel cytokine remains unknown. Here, we report for the first...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-08, Vol.262 (1), p.14-19
Hauptverfasser:	Subramaniam, S.Vaidyanathan, Cooper, Roland S., Adunyah, Samuel E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western DNA-Binding Proteins - metabolism Humans Interleukin-17 - pharmacology Janus Kinase 1 Janus Kinase 2 Janus Kinase 3 Phosphorylation - drug effects Phosphotyrosine - metabolism Precipitin Tests Protein-Tyrosine Kinases - metabolism Proteins - metabolism Proto-Oncogene Proteins Receptors, Interleukin - analysis Receptors, Interleukin-17 Recombinant Proteins - analysis Signal Transduction - drug effects STAT1 Transcription Factor STAT2 Transcription Factor STAT3 Transcription Factor STAT4 Transcription Factor Time Factors Trans-Activators - metabolism TYK2 Kinase U937 Cells
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