Haemolipodialysis
Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and man...
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| Veröffentlicht in: | Blood purification 1999-01, Vol.17 (2-3), p.127-133 |
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| container_end_page | 133 |
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| container_issue | 2-3 |
| container_start_page | 127 |
| container_title | Blood purification |
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| creator | Wratten, M.L. Navino, C. Tetta, C. Verzetti, G. |
| description | Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing α-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. This technique may provide a new approach in preventing free radical-associated pathologies in chronic haemodialysis patients. |
| doi_str_mv | 10.1159/000014384 |
| format | Article |
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This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing α-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. This technique may provide a new approach in preventing free radical-associated pathologies in chronic haemodialysis patients.</description><identifier>ISSN: 0253-5068</identifier><identifier>ISBN: 3805569181</identifier><identifier>ISBN: 9783805569187</identifier><identifier>EISSN: 1421-9735</identifier><identifier>EISBN: 3318004642</identifier><identifier>EISBN: 9783318004649</identifier><identifier>DOI: 10.1159/000014384</identifier><identifier>PMID: 10449870</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Ascorbic Acid ; Cardiovascular Diseases - prevention & control ; Humans ; Liposomes ; Oxidative Stress ; Renal Dialysis - adverse effects ; Vitamin E</subject><ispartof>Blood purification, 1999-01, Vol.17 (2-3), p.127-133</ispartof><rights>1999 S. 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This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing α-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. This technique may provide a new approach in preventing free radical-associated pathologies in chronic haemodialysis patients.</description><subject>Ascorbic Acid</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Humans</subject><subject>Liposomes</subject><subject>Oxidative Stress</subject><subject>Renal Dialysis - adverse effects</subject><subject>Vitamin E</subject><issn>0253-5068</issn><issn>1421-9735</issn><isbn>3805569181</isbn><isbn>9783805569187</isbn><isbn>3318004642</isbn><isbn>9783318004649</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtPw0AQhI-XyAOK1EgUFEgUht17XxkiIEiRoCD16WzfIYONjS8p8u9xcAQUbLPFfDPaHUImCNeIwtxAN8iZ5ntkxBhqAC453SdD5BQTo5g46AQNQkiDGg_JEKhgiQCpB2QU49vWLoU5JgMEzo1WMCSTufNVXRZNnReu3MQinpCj4MroT3d7TJb3dy-zebJ4enicTRdJxqheJRlVVNLcK5_xwJwTqUpZAMlCqgU4jikIjd0hGWBuFHUulSoXSorAuELDxuSyz23a-nPt48pWRcx8WboPX6-jlcZo5EJ34FUPZm0dY-uDbdqicu3GIthtM_anmY4934Wu08rnf8j-4Q4464F317769hfY2S_-VW-fl9-AbfLAvgAPHGsT</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Wratten, M.L.</creator><creator>Navino, C.</creator><creator>Tetta, C.</creator><creator>Verzetti, G.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Haemolipodialysis</title><author>Wratten, M.L. ; Navino, C. ; Tetta, C. ; Verzetti, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-c27262de7ec4f3aa5b7b3f063fb850a41b0581918c01d972aab67d5765f347193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Ascorbic Acid</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Humans</topic><topic>Liposomes</topic><topic>Oxidative Stress</topic><topic>Renal Dialysis - adverse effects</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wratten, M.L.</creatorcontrib><creatorcontrib>Navino, C.</creatorcontrib><creatorcontrib>Tetta, C.</creatorcontrib><creatorcontrib>Verzetti, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood purification</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wratten, M.L.</au><au>Navino, C.</au><au>Tetta, C.</au><au>Verzetti, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemolipodialysis</atitle><jtitle>Blood purification</jtitle><addtitle>Blood Purif</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>17</volume><issue>2-3</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0253-5068</issn><eissn>1421-9735</eissn><isbn>3805569181</isbn><isbn>9783805569187</isbn><eisbn>3318004642</eisbn><eisbn>9783318004649</eisbn><abstract>Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing α-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. 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| fulltext | fulltext |
| identifier | ISSN: 0253-5068 |
| ispartof | Blood purification, 1999-01, Vol.17 (2-3), p.127-133 |
| issn | 0253-5068 1421-9735 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69981458 |
| source | MEDLINE; Karger Journals Complete |
| subjects | Ascorbic Acid Cardiovascular Diseases - prevention & control Humans Liposomes Oxidative Stress Renal Dialysis - adverse effects Vitamin E |
| title | Haemolipodialysis |
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