Haemolipodialysis

Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing α-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. This technique may provide a new approach in preventing free radical-associated pathologies in chronic haemodialysis patients.