Association of cyclin D1 expression in lung cancer and the smoking habits of patients
This study examined whether or not cyclin D1 expression is associated with the smoking habits of patients with non-small cell lung carcinomas (NSCLC). Immunohistochemistry was used to analyze 181 NSCLC samples for the expression of cyclin D1. Expression of cyclin D1 protein was found in 130 out of 1...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 1999-07, Vol.141 (1), p.147-150 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 150 |
|---|---|
| container_issue | 1 |
| container_start_page | 147 |
| container_title | Cancer letters |
| container_volume | 141 |
| creator | Volm, M Koomägi, R |
| description | This study examined whether or not cyclin D1 expression is associated with the smoking habits of patients with non-small cell lung carcinomas (NSCLC). Immunohistochemistry was used to analyze 181 NSCLC samples for the expression of cyclin D1. Expression of cyclin D1 protein was found in 130 out of 181 cases (72%). A significant relationship between cyclin D1 expression and stage or histological classification was not observed. The carcinomas of smokers expressed cyclin D1 in 77% of the cases while carcinomas of non-smokers expressed this protein only 57% of the time (
P |
| doi_str_mv | 10.1016/S0304-3835(99)00097-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69980271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030438359900097X</els_id><sourcerecordid>69980271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-4cdf295d1f75b17f769228f66fb830bfe49b8898ad927e99e68ab93fe5d642063</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhi3UChbKT6DKoargEGo7dmyfKsS3hMQBkLhZjjMGt9lk8WQR_Ps67Ap64zTSq-edGT2E7DF6yCirf93Qioqy0pXcN-aAUmpUeb9BZkwrXiqj6Rcye0e2yDbinwxJoeQm2WJUSMGlnJG7I8TBRzfGoS-GUPhX38W-OGEFvCwSIE55Drpl_1B413tIhevbYnyEAufD35jjR9fEEaf2Iu-BfsRv5GtwHcLueu6Qu7PT2-OL8ur6_PL46Kr0grOxFL4N3MiWBSUbpoKqDec61HVodEWbAMI0WhvtWsMVGAO1do2pAsi2FpzW1Q75udq7SMPTEnC084geus71MCzR1iaL4Ip9CjIlJaeCZ1CuQJ8GxATBLlKcu_RqGbWTePsm3k5WrTH2Tby9z73v6wPLZg7tf62V6Qz8WAMOvetCyi4jfnBaaM6m-79XGGRtzxGSRZ-VemhjAj_adoiffPIP3PmfDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17552042</pqid></control><display><type>article</type><title>Association of cyclin D1 expression in lung cancer and the smoking habits of patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Volm, M ; Koomägi, R</creator><creatorcontrib>Volm, M ; Koomägi, R</creatorcontrib><description>This study examined whether or not cyclin D1 expression is associated with the smoking habits of patients with non-small cell lung carcinomas (NSCLC). Immunohistochemistry was used to analyze 181 NSCLC samples for the expression of cyclin D1. Expression of cyclin D1 protein was found in 130 out of 181 cases (72%). A significant relationship between cyclin D1 expression and stage or histological classification was not observed. The carcinomas of smokers expressed cyclin D1 in 77% of the cases while carcinomas of non-smokers expressed this protein only 57% of the time (
P<0.01, Fisher's exact test). The correlation between smoking and cyclin D1 expression was maintained when the analysis was limited to squamous cell lung carcinomas. However, no correlation was found between cyclin D1 expression and the smoking habits of patients with adenocarcinomas. This can be explained by the fact that the development of adenocarcinomas – in contrast to squamous cell lung carcinomas – is not closely related to tobacco smoke.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(99)00097-X</identifier><identifier>PMID: 10454255</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenocarcinoma - metabolism ; Adult ; Aged ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Squamous Cell - metabolism ; Cyclin D1 ; Cyclin D1 - biosynthesis ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms - metabolism ; Male ; Medical sciences ; Middle Aged ; Non-small cell lung carcinomas ; Pneumology ; Smoking ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer letters, 1999-07, Vol.141 (1), p.147-150</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-4cdf295d1f75b17f769228f66fb830bfe49b8898ad927e99e68ab93fe5d642063</citedby><cites>FETCH-LOGICAL-c421t-4cdf295d1f75b17f769228f66fb830bfe49b8898ad927e99e68ab93fe5d642063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030438359900097X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1848212$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10454255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volm, M</creatorcontrib><creatorcontrib>Koomägi, R</creatorcontrib><title>Association of cyclin D1 expression in lung cancer and the smoking habits of patients</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>This study examined whether or not cyclin D1 expression is associated with the smoking habits of patients with non-small cell lung carcinomas (NSCLC). Immunohistochemistry was used to analyze 181 NSCLC samples for the expression of cyclin D1. Expression of cyclin D1 protein was found in 130 out of 181 cases (72%). A significant relationship between cyclin D1 expression and stage or histological classification was not observed. The carcinomas of smokers expressed cyclin D1 in 77% of the cases while carcinomas of non-smokers expressed this protein only 57% of the time (
P<0.01, Fisher's exact test). The correlation between smoking and cyclin D1 expression was maintained when the analysis was limited to squamous cell lung carcinomas. However, no correlation was found between cyclin D1 expression and the smoking habits of patients with adenocarcinomas. This can be explained by the fact that the development of adenocarcinomas – in contrast to squamous cell lung carcinomas – is not closely related to tobacco smoke.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Cyclin D1</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non-small cell lung carcinomas</subject><subject>Pneumology</subject><subject>Smoking</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3UChbKT6DKoargEGo7dmyfKsS3hMQBkLhZjjMGt9lk8WQR_Ps67Ap64zTSq-edGT2E7DF6yCirf93Qioqy0pXcN-aAUmpUeb9BZkwrXiqj6Rcye0e2yDbinwxJoeQm2WJUSMGlnJG7I8TBRzfGoS-GUPhX38W-OGEFvCwSIE55Drpl_1B413tIhevbYnyEAufD35jjR9fEEaf2Iu-BfsRv5GtwHcLueu6Qu7PT2-OL8ur6_PL46Kr0grOxFL4N3MiWBSUbpoKqDec61HVodEWbAMI0WhvtWsMVGAO1do2pAsi2FpzW1Q75udq7SMPTEnC084geus71MCzR1iaL4Ip9CjIlJaeCZ1CuQJ8GxATBLlKcu_RqGbWTePsm3k5WrTH2Tby9z73v6wPLZg7tf62V6Qz8WAMOvetCyi4jfnBaaM6m-79XGGRtzxGSRZ-VemhjAj_adoiffPIP3PmfDw</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Volm, M</creator><creator>Koomägi, R</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Association of cyclin D1 expression in lung cancer and the smoking habits of patients</title><author>Volm, M ; Koomägi, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-4cdf295d1f75b17f769228f66fb830bfe49b8898ad927e99e68ab93fe5d642063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Cyclin D1</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non-small cell lung carcinomas</topic><topic>Pneumology</topic><topic>Smoking</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volm, M</creatorcontrib><creatorcontrib>Koomägi, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volm, M</au><au>Koomägi, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of cyclin D1 expression in lung cancer and the smoking habits of patients</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>141</volume><issue>1</issue><spage>147</spage><epage>150</epage><pages>147-150</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>This study examined whether or not cyclin D1 expression is associated with the smoking habits of patients with non-small cell lung carcinomas (NSCLC). Immunohistochemistry was used to analyze 181 NSCLC samples for the expression of cyclin D1. Expression of cyclin D1 protein was found in 130 out of 181 cases (72%). A significant relationship between cyclin D1 expression and stage or histological classification was not observed. The carcinomas of smokers expressed cyclin D1 in 77% of the cases while carcinomas of non-smokers expressed this protein only 57% of the time (
P<0.01, Fisher's exact test). The correlation between smoking and cyclin D1 expression was maintained when the analysis was limited to squamous cell lung carcinomas. However, no correlation was found between cyclin D1 expression and the smoking habits of patients with adenocarcinomas. This can be explained by the fact that the development of adenocarcinomas – in contrast to squamous cell lung carcinomas – is not closely related to tobacco smoke.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10454255</pmid><doi>10.1016/S0304-3835(99)00097-X</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1999-07, Vol.141 (1), p.147-150 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69980271 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenocarcinoma - metabolism Adult Aged Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Squamous Cell - metabolism Cyclin D1 Cyclin D1 - biosynthesis Female Humans Immunohistochemistry Lung Neoplasms - metabolism Male Medical sciences Middle Aged Non-small cell lung carcinomas Pneumology Smoking Tumors of the respiratory system and mediastinum |
| title | Association of cyclin D1 expression in lung cancer and the smoking habits of patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T07%3A59%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20cyclin%20D1%20expression%20in%20lung%20cancer%20and%20the%20smoking%20habits%20of%20patients&rft.jtitle=Cancer%20letters&rft.au=Volm,%20M&rft.date=1999-07-01&rft.volume=141&rft.issue=1&rft.spage=147&rft.epage=150&rft.pages=147-150&rft.issn=0304-3835&rft.eissn=1872-7980&rft.coden=CALEDQ&rft_id=info:doi/10.1016/S0304-3835(99)00097-X&rft_dat=%3Cproquest_cross%3E69980271%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17552042&rft_id=info:pmid/10454255&rft_els_id=S030438359900097X&rfr_iscdi=true |