DNA ligase gene disruptions can depress viral growth and replication in poxvirus-infected cells

Poxvirus-encoded DNA ligases are assumed to play a role in viral DNA replication; however mutational inactivation of vaccinia ligase has not been reported to affect viral growth rates in culture. This communication re-examines this surprising aspect of poxviral biology using both Shope fibroma virus...

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Veröffentlicht in:	Virus research 1998-08, Vol.56 (2), p.135-147
Hauptverfasser:	Parks, Robin J, Winchcombe-Forhan, C, DeLange, A.M, Xing, X, Evans, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line - virology DNA ligase DNA Ligases - deficiency DNA, Viral - biosynthesis Etoposide Etoposide - pharmacology Fibroma Virus, Rabbit - enzymology Fibroma Virus, Rabbit - growth & development Genes, Viral - drug effects Genes, Viral - radiation effects Mutation Nucleic Acid Synthesis Inhibitors - pharmacology Phenotype Poxviridae - genetics Poxviridae - physiology Rabbits Recombination Recombination, Genetic Replication Shope fibroma virus Ultraviolet Rays Vaccinia virus Vaccinia virus - enzymology Vaccinia virus - growth & development Virus Replication - genetics
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