Isolation and identification of a metabolite of cidofovir from rat kidney

Cidofovir is an acyclic nucleotide analog with potent and broad-spectrum antiviral activity against adenoviruses and herpesviruses including cytomegalovirus (CMV). Cidofovir undergoes intracellular phosphorylation by host enzymes to cidofovir phosphate and cidofovir diphosphate (the active form). An...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1998-04, Vol.16 (8), p.1349-1356
Hauptverfasser:	Eisenberg, Eugene J, Lynch, Geoffrey R, Bidgood, Alison M, Krishnamurty, Krish, Cundy, Kenneth C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiviral Agents - administration & dosage Antiviral Agents - isolation & purification Antiviral Agents - metabolism Biological and medical sciences Chromatography, High Pressure Liquid - methods Cidofovir Cidofovir–phosphocholine Cytosine - administration & dosage Cytosine - analogs & derivatives Cytosine - isolation & purification Cytosine - metabolism Dose-Response Relationship, Drug Drug metabolism General pharmacology High-performance liquid chromatography Injections, Intravenous Kidney Kidney - chemistry Kidney - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Nuclear magnetic resonance Organophosphonates Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - isolation & purification Organophosphorus Compounds - metabolism Pharmacology. Drug treatments Rats
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