Melanocortin receptors and antagonists regulate pigmentation and body weight

The action of two genetic loci—agouti and the melanocortin receptor‐1 (Mc1r)—have opposing effects in the control of mammalian pigmentation and ultimately determine the color of the pigment produced. In a recent paper, Ollmann et al. confirmed that the agouti protein acts via the Mc1r. They show tha...

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Veröffentlicht in:	BioEssays 1998-08, Vol.20 (8), p.603-606
Hauptverfasser:	Jordan, Siobhán, Jackson, Ian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti Signaling Protein alpha-MSH - antagonists & inhibitors alpha-MSH - physiology Animals Body Weight Hair Color - genetics Hair Color - physiology Intercellular Signaling Peptides and Proteins Mammals Mice Mice, Mutant Strains Proteins - physiology Receptors, Corticotropin - antagonists & inhibitors Receptors, Corticotropin - physiology Receptors, Melanocortin
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