N-Acetylcysteine Enhances Endothelium-Dependent Vasorelaxation in the Isolated Rat Mesenteric Artery

Study Hypothesis: Previous studies have suggested that N-Acetylcysteine (NAC) may confer additional protection in acetaminophen (APAP) overdose by improving hepatic microcirculation. We hypothesize that NAC enhances release of nitric oxide (NO) from the vasculature. Methods: Sprague-Dawley rat super...

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Veröffentlicht in:	Annals of emergency medicine 1998-10, Vol.32 (4), p.405-410
Hauptverfasser:	Lopez, Bernard L, Snyder, Jack W, Birenbaum, Dale S, Ma, Xin-liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Acetylcysteine - pharmacology Analysis of Variance Animals Biological and medical sciences Calcimycin - pharmacology Dose-Response Relationship, Drug Drug intoxications. Doping Endothelium, Vascular - drug effects Glutathione - pharmacology In Vitro Techniques Medical sciences Mesenteric Arteries - drug effects Methionine - analogs & derivatives Methionine - pharmacology Pharmacology. Drug treatments Rats Vasodilation - drug effects Vasodilator Agents - pharmacology
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