Comparison of ketorolac and diclofenac in the treatment of renal colic
To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic. In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluat...
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| Veröffentlicht in: | European journal of clinical pharmacology 1998-08, Vol.54 (6), p.455-458 |
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| container_title | European journal of clinical pharmacology |
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| creator | COHEN, E HAFNER, R ROTENBERG, Z FADILLA, M GARTY, M |
| description | To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic.
In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.
There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.
Ketorolac and diclofenac are equally effective in the treatment of renal colic. |
| doi_str_mv | 10.1007/s002280050492 |
| format | Article |
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In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.
There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.
Ketorolac and diclofenac are equally effective in the treatment of renal colic.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s002280050492</identifier><identifier>PMID: 9776434</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Analgesics, Non-Narcotic - therapeutic use ; Analysis of Variance ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Colic - drug therapy ; Colic - etiology ; Diclofenac - therapeutic use ; Double-Blind Method ; Drug therapy ; Female ; Humans ; Ketorolac ; Kidney Diseases - complications ; Kidney Diseases - drug therapy ; Male ; Medical research ; Medical sciences ; Middle Aged ; Pain ; Pharmacology. Drug treatments ; Time Factors ; Tolmetin - analogs & derivatives ; Tolmetin - therapeutic use ; Treatment Outcome</subject><ispartof>European journal of clinical pharmacology, 1998-08, Vol.54 (6), p.455-458</ispartof><rights>1998 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-8e18639b31c404d997f1d0c5f09a83d483304be983414669de9521fcd7b751dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,778,782,787,788,23917,23918,25127,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2395284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9776434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COHEN, E</creatorcontrib><creatorcontrib>HAFNER, R</creatorcontrib><creatorcontrib>ROTENBERG, Z</creatorcontrib><creatorcontrib>FADILLA, M</creatorcontrib><creatorcontrib>GARTY, M</creatorcontrib><title>Comparison of ketorolac and diclofenac in the treatment of renal colic</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic.
In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.
There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.
Ketorolac and diclofenac are equally effective in the treatment of renal colic.</description><subject>Adult</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Analysis of Variance</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Colic - drug therapy</subject><subject>Colic - etiology</subject><subject>Diclofenac - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Ketorolac</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - drug therapy</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Colic - drug therapy</topic><topic>Colic - etiology</topic><topic>Diclofenac - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Ketorolac</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - drug therapy</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Tolmetin - analogs & derivatives</topic><topic>Tolmetin - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COHEN, E</creatorcontrib><creatorcontrib>HAFNER, R</creatorcontrib><creatorcontrib>ROTENBERG, Z</creatorcontrib><creatorcontrib>FADILLA, M</creatorcontrib><creatorcontrib>GARTY, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COHEN, E</au><au>HAFNER, R</au><au>ROTENBERG, Z</au><au>FADILLA, M</au><au>GARTY, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of ketorolac and diclofenac in the treatment of renal colic</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>54</volume><issue>6</issue><spage>455</spage><epage>458</epage><pages>455-458</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>To compare the efficacy and adverse effects of ketorolac and diclofenac in the treatment of renal colic.
In a double-blind, randomized clinical trial, 57 patients admitted to the emergency room for renal colic, received either 30 mg of ketorolac or 75 mg of diclofenac i.m. (intramuscularly). Evaluations were performed at 1, 2 h and 6 h after treatment. Pain was assessed by a four-point verbal rating scale (VRS) and a visual analogue scale (VAS). Only patients with at least moderate pain according to the VRS were included. Seventy-five milligrams of pethidine i.m. was given as rescue medicine, if insufficient analgesia was achieved. The adverse effects recorded were sedation, nausea and vomiting.
There was no significant difference between ketorolac and diclofenac, with respect to pain level over time, the number of patients requiring rescue medicine, or the level of adverse effects.
Ketorolac and diclofenac are equally effective in the treatment of renal colic.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>9776434</pmid><doi>10.1007/s002280050492</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1998-08, Vol.54 (6), p.455-458 |
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| subjects | Adult Analgesics, Non-Narcotic - therapeutic use Analysis of Variance Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Colic - drug therapy Colic - etiology Diclofenac - therapeutic use Double-Blind Method Drug therapy Female Humans Ketorolac Kidney Diseases - complications Kidney Diseases - drug therapy Male Medical research Medical sciences Middle Aged Pain Pharmacology. Drug treatments Time Factors Tolmetin - analogs & derivatives Tolmetin - therapeutic use Treatment Outcome |
| title | Comparison of ketorolac and diclofenac in the treatment of renal colic |
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