The role of inherited thrombophilia in venous thromboembolism associated with pregnancy
Venous thromboembolism is an important cause of maternal morbidity and mortality. The puerperium should be regarded as the period of greatest risk. However, fatalities in early pregnancy emphasise the need to assess thrombotic risk at all stages of pregnancy. In many cases those at increased risk ar...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1999-08, Vol.106 (8), p.756-766 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | McColl, M. D. Walker, I. D. Greer, I. A. |
| description | Venous thromboembolism is an important cause of maternal morbidity and mortality. The puerperium should be regarded as the period of greatest risk. However, fatalities in early pregnancy emphasise the need to assess thrombotic risk at all stages of pregnancy. In many cases those at increased risk are potentially identifiable on clinical grounds alone such as those with a personal or family history of venous thromboembolism, obesity, or surgery. Identification of women with multiple clinical risks for thrombosis during pregnancy remains the key to reducing the incidence of this condition. In women who present with a personal or family history of proven venous thromboembolism, thrombophilia screening should be performed in early pregnancy, since the results may influence subsequent management during pregnancy. The investigation and management of patients considered at increased risk of venous thrombosis during pregnancy requires close liaison between obstetricians and haematologists familiar with this rapidly expanding and complex field of thrombophilia. |
| doi_str_mv | 10.1111/j.1471-0528.1999.tb08395.x |
| format | Article |
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D. ; Walker, I. D. ; Greer, I. A.</creator><creatorcontrib>McColl, M. D. ; Walker, I. D. ; Greer, I. A.</creatorcontrib><description>Venous thromboembolism is an important cause of maternal morbidity and mortality. The puerperium should be regarded as the period of greatest risk. However, fatalities in early pregnancy emphasise the need to assess thrombotic risk at all stages of pregnancy. In many cases those at increased risk are potentially identifiable on clinical grounds alone such as those with a personal or family history of venous thromboembolism, obesity, or surgery. Identification of women with multiple clinical risks for thrombosis during pregnancy remains the key to reducing the incidence of this condition. In women who present with a personal or family history of proven venous thromboembolism, thrombophilia screening should be performed in early pregnancy, since the results may influence subsequent management during pregnancy. The investigation and management of patients considered at increased risk of venous thrombosis during pregnancy requires close liaison between obstetricians and haematologists familiar with this rapidly expanding and complex field of thrombophilia.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>EISSN: 1365-215X</identifier><identifier>DOI: 10.1111/j.1471-0528.1999.tb08395.x</identifier><identifier>PMID: 10453824</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Activated Protein C Resistance - genetics ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Factor V - genetics ; Female ; Genetic Predisposition to Disease ; Hematologic and hematopoietic diseases ; Humans ; Hyperhomocysteinemia - genetics ; Medical sciences ; Mutation - genetics ; Platelet diseases and coagulopathies ; Pregnancy ; Pregnancy Complications, Cardiovascular - mortality ; Prothrombin - genetics ; Risk Factors ; Thromboembolism - complications ; Thromboembolism - genetics ; Thromboembolism - mortality ; Thrombophilia - complications ; Thrombophilia - genetics</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1999-08, Vol.106 (8), p.756-766</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3996-5b3f7117c43156ee3bb5c06291f14c8f02918f3a1c18f14abce79d728a4c08a73</citedby><cites>FETCH-LOGICAL-c3996-5b3f7117c43156ee3bb5c06291f14c8f02918f3a1c18f14abce79d728a4c08a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.1999.tb08395.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.1999.tb08395.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1899420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10453824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McColl, M. D.</creatorcontrib><creatorcontrib>Walker, I. D.</creatorcontrib><creatorcontrib>Greer, I. A.</creatorcontrib><title>The role of inherited thrombophilia in venous thromboembolism associated with pregnancy</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>Venous thromboembolism is an important cause of maternal morbidity and mortality. The puerperium should be regarded as the period of greatest risk. However, fatalities in early pregnancy emphasise the need to assess thrombotic risk at all stages of pregnancy. In many cases those at increased risk are potentially identifiable on clinical grounds alone such as those with a personal or family history of venous thromboembolism, obesity, or surgery. Identification of women with multiple clinical risks for thrombosis during pregnancy remains the key to reducing the incidence of this condition. In women who present with a personal or family history of proven venous thromboembolism, thrombophilia screening should be performed in early pregnancy, since the results may influence subsequent management during pregnancy. The investigation and management of patients considered at increased risk of venous thrombosis during pregnancy requires close liaison between obstetricians and haematologists familiar with this rapidly expanding and complex field of thrombophilia.</description><subject>Activated Protein C Resistance - genetics</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - genetics</subject><subject>Medical sciences</subject><subject>Mutation - genetics</subject><subject>Platelet diseases and coagulopathies</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - mortality</subject><subject>Prothrombin - genetics</subject><subject>Risk Factors</subject><subject>Thromboembolism - complications</subject><subject>Thromboembolism - genetics</subject><subject>Thromboembolism - mortality</subject><subject>Thrombophilia - complications</subject><subject>Thrombophilia - genetics</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNtLwzAUxoMobk7_BSkivrUmTS-JD4IOrwz2MvExpNmpzehlJp3b_ntTVy-vBsI5nHzfyccPoTOCA-LO5SIgUUp8HIcsIJzzoM0wozwONnto-PO0_9VjH9OQDdCRtQuMSRJieogGBEcxZWE0RK-zAjzTlOA1uafrAoxuYe61hWmqrFkWutTSzb0PqJuV_Z6Du6W2lSetbZSWnWWt28JbGnirZa22x-ggl6WFk76O0Mv93Wz86E-mD0_jm4mvKOeJH2c0TwlJVURJnADQLIsVTkJOchIplmPXsZxKolwhkcwUpHyehkxGCjOZ0hG62O1dmuZ9BbYVlbYKylLW4AKLhPM0iSl2wqudUJnGWgO5WBpdSbMVBIsOq1iIjp3o2IkOq-ixio0zn_a_rLIK5n-sO45OcN4LpFWyzI1joO2vjnEehV2I651srUvY_iOBuH2epnFCPwE_7JWn</recordid><startdate>199908</startdate><enddate>199908</enddate><creator>McColl, M. D.</creator><creator>Walker, I. D.</creator><creator>Greer, I. A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199908</creationdate><title>The role of inherited thrombophilia in venous thromboembolism associated with pregnancy</title><author>McColl, M. D. ; Walker, I. D. ; Greer, I. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3996-5b3f7117c43156ee3bb5c06291f14c8f02918f3a1c18f14abce79d728a4c08a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Activated Protein C Resistance - genetics</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - genetics</topic><topic>Medical sciences</topic><topic>Mutation - genetics</topic><topic>Platelet diseases and coagulopathies</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - mortality</topic><topic>Prothrombin - genetics</topic><topic>Risk Factors</topic><topic>Thromboembolism - complications</topic><topic>Thromboembolism - genetics</topic><topic>Thromboembolism - mortality</topic><topic>Thrombophilia - complications</topic><topic>Thrombophilia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McColl, M. D.</creatorcontrib><creatorcontrib>Walker, I. D.</creatorcontrib><creatorcontrib>Greer, I. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McColl, M. D.</au><au>Walker, I. D.</au><au>Greer, I. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of inherited thrombophilia in venous thromboembolism associated with pregnancy</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1999-08</date><risdate>1999</risdate><volume>106</volume><issue>8</issue><spage>756</spage><epage>766</epage><pages>756-766</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>Venous thromboembolism is an important cause of maternal morbidity and mortality. The puerperium should be regarded as the period of greatest risk. However, fatalities in early pregnancy emphasise the need to assess thrombotic risk at all stages of pregnancy. In many cases those at increased risk are potentially identifiable on clinical grounds alone such as those with a personal or family history of venous thromboembolism, obesity, or surgery. Identification of women with multiple clinical risks for thrombosis during pregnancy remains the key to reducing the incidence of this condition. In women who present with a personal or family history of proven venous thromboembolism, thrombophilia screening should be performed in early pregnancy, since the results may influence subsequent management during pregnancy. The investigation and management of patients considered at increased risk of venous thrombosis during pregnancy requires close liaison between obstetricians and haematologists familiar with this rapidly expanding and complex field of thrombophilia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10453824</pmid><doi>10.1111/j.1471-0528.1999.tb08395.x</doi><tpages>11</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Activated Protein C Resistance - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Factor V - genetics Female Genetic Predisposition to Disease Hematologic and hematopoietic diseases Humans Hyperhomocysteinemia - genetics Medical sciences Mutation - genetics Platelet diseases and coagulopathies Pregnancy Pregnancy Complications, Cardiovascular - mortality Prothrombin - genetics Risk Factors Thromboembolism - complications Thromboembolism - genetics Thromboembolism - mortality Thrombophilia - complications Thrombophilia - genetics |
| title | The role of inherited thrombophilia in venous thromboembolism associated with pregnancy |
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