Decreased Soluble Adhesion Molecule L-Selectin Plasma Concentrations after Major Trauma
BACKGROUNDBinding of the leukocyte glycoprotein L-selectin to ligands expressed by activated endothelium directs leukocyte recruitment to areas of acute inflammation. Sequestration by activated microvascular endothelium has been proposed to explain the low plasma concentrations of soluble L-selectin...
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| Veröffentlicht in: | The Journal of Trauma: Injury, Infection, and Critical Care Infection, and Critical Care, 1998-10, Vol.45 (4), p.705-708 |
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| container_title | The Journal of Trauma: Injury, Infection, and Critical Care |
| container_volume | 45 |
| creator | Muller, Jorg C. Buhrer, Christoph Kiening, Karl L. Kerner, Thoralf Gerlach, Herwig Obladen, Michael Unterberg, Andreas W. Lanksch, Wolfgang R. |
| description | BACKGROUNDBinding of the leukocyte glycoprotein L-selectin to ligands expressed by activated endothelium directs leukocyte recruitment to areas of acute inflammation. Sequestration by activated microvascular endothelium has been proposed to explain the low plasma concentrations of soluble L-selectin (sCD62L) observed early in patients with acute respiratory distress syndrome. We hypothesized that inflammatory endothelial activation may occur in trauma patients, leading to decreased sCD62L plasma concentrations.
METHODSThis study was a prospective analysis of sCD62L plasma concentrations in patients with isolated head injuries and multiple trauma patients without head injuries admitted to two tertiary-level intensive care units. sCD62L plasma concentrations were determined in 18 consecutive adult patients with isolated moderate and severe head injuries and in 13 multiple trauma patients without head injuries immediately upon admission to the intensive care unit and then daily for up to 10 days after trauma.
RESULTSCompared with healthy adult controls (n = 22), patient sCD62L plasma concentrations were significantly decreased upon admission (5.7 +/- 1.6 vs. 11.0 +/- 1.7 pmol/mL; p < 0.001). In all patients, sCD62L concentrations remained depressed throughout the study period. sCD62L concentrations did not differ significantly between patients with isolated head injuries and multiple trauma patients without head injuries, although repeated-measures analysis of variance showed significantly more depressed sCD62L concentrations associated with severe (n = 14) compared with moderate head injuries (n = 4) during the study period (p < 0.05).
CONCLUSIONPatients with major trauma present with a significant reduction of sCD62L plasma concentrations within the first 12 hours after trauma and during subsequent intensive care. This finding suggests widespread microvascular endothelial activation after trauma, which may be associated with increased neutrophil extravasation. |
| doi_str_mv | 10.1097/00005373-199810000-00013 |
| format | Article |
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METHODSThis study was a prospective analysis of sCD62L plasma concentrations in patients with isolated head injuries and multiple trauma patients without head injuries admitted to two tertiary-level intensive care units. sCD62L plasma concentrations were determined in 18 consecutive adult patients with isolated moderate and severe head injuries and in 13 multiple trauma patients without head injuries immediately upon admission to the intensive care unit and then daily for up to 10 days after trauma.
RESULTSCompared with healthy adult controls (n = 22), patient sCD62L plasma concentrations were significantly decreased upon admission (5.7 +/- 1.6 vs. 11.0 +/- 1.7 pmol/mL; p < 0.001). In all patients, sCD62L concentrations remained depressed throughout the study period. sCD62L concentrations did not differ significantly between patients with isolated head injuries and multiple trauma patients without head injuries, although repeated-measures analysis of variance showed significantly more depressed sCD62L concentrations associated with severe (n = 14) compared with moderate head injuries (n = 4) during the study period (p < 0.05).
CONCLUSIONPatients with major trauma present with a significant reduction of sCD62L plasma concentrations within the first 12 hours after trauma and during subsequent intensive care. This finding suggests widespread microvascular endothelial activation after trauma, which may be associated with increased neutrophil extravasation.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/00005373-199810000-00013</identifier><identifier>PMID: 9783608</identifier><identifier>CODEN: JOTRA5</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Case-Control Studies ; Craniocerebral Trauma - blood ; Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine ; Humans ; Intensive care medicine ; L-Selectin - blood ; Medical sciences ; Middle Aged ; Multiple Trauma - blood ; Prospective Studies ; Reference Values</subject><ispartof>The Journal of Trauma: Injury, Infection, and Critical Care, 1998-10, Vol.45 (4), p.705-708</ispartof><rights>Williams & Wilkins 1998. All Rights Reserved.</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3843-4f680f0078f940f980ebb49e6b0409ad416bd1bb50e9a0c8ed84b21ba7880f083</citedby><cites>FETCH-LOGICAL-c3843-4f680f0078f940f980ebb49e6b0409ad416bd1bb50e9a0c8ed84b21ba7880f083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2422469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9783608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muller, Jorg C.</creatorcontrib><creatorcontrib>Buhrer, Christoph</creatorcontrib><creatorcontrib>Kiening, Karl L.</creatorcontrib><creatorcontrib>Kerner, Thoralf</creatorcontrib><creatorcontrib>Gerlach, Herwig</creatorcontrib><creatorcontrib>Obladen, Michael</creatorcontrib><creatorcontrib>Unterberg, Andreas W.</creatorcontrib><creatorcontrib>Lanksch, Wolfgang R.</creatorcontrib><title>Decreased Soluble Adhesion Molecule L-Selectin Plasma Concentrations after Major Trauma</title><title>The Journal of Trauma: Injury, Infection, and Critical Care</title><addtitle>J Trauma</addtitle><description>BACKGROUNDBinding of the leukocyte glycoprotein L-selectin to ligands expressed by activated endothelium directs leukocyte recruitment to areas of acute inflammation. Sequestration by activated microvascular endothelium has been proposed to explain the low plasma concentrations of soluble L-selectin (sCD62L) observed early in patients with acute respiratory distress syndrome. We hypothesized that inflammatory endothelial activation may occur in trauma patients, leading to decreased sCD62L plasma concentrations.
METHODSThis study was a prospective analysis of sCD62L plasma concentrations in patients with isolated head injuries and multiple trauma patients without head injuries admitted to two tertiary-level intensive care units. sCD62L plasma concentrations were determined in 18 consecutive adult patients with isolated moderate and severe head injuries and in 13 multiple trauma patients without head injuries immediately upon admission to the intensive care unit and then daily for up to 10 days after trauma.
RESULTSCompared with healthy adult controls (n = 22), patient sCD62L plasma concentrations were significantly decreased upon admission (5.7 +/- 1.6 vs. 11.0 +/- 1.7 pmol/mL; p < 0.001). In all patients, sCD62L concentrations remained depressed throughout the study period. sCD62L concentrations did not differ significantly between patients with isolated head injuries and multiple trauma patients without head injuries, although repeated-measures analysis of variance showed significantly more depressed sCD62L concentrations associated with severe (n = 14) compared with moderate head injuries (n = 4) during the study period (p < 0.05).
CONCLUSIONPatients with major trauma present with a significant reduction of sCD62L plasma concentrations within the first 12 hours after trauma and during subsequent intensive care. This finding suggests widespread microvascular endothelial activation after trauma, which may be associated with increased neutrophil extravasation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Craniocerebral Trauma - blood</subject><subject>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>L-Selectin - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Trauma - blood</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rHCEUhqWkpEuan1DwIvRuGr9mRi_DNm0DG1pISi_l6Jxhp3HGVGcI-fd1s5u9iyAePc-r8EgI5ewLZ6a9ZGXUspUVN0bz3a4qk8t3ZMVrYSqtmTkhK8aEqGqhxQdynvPgCiPq1gh9Sk5Nq2XD9Ir8-Yo-IWTs6F0MiwtIr7ot5iFO9DYG9Es52VR3WMp5mOivAHkEuo6Tx2lOMBcwU-hnTPQW_sZE7xMsI3wk73sIGc8P6xn5_e36fv2j2vz8frO-2lReaiUr1Tea9Yy1ujeK9UYzdE4ZbBxTzECneOM67lzN0ADzGjutnOAOWr3LaXlGPu_vfUzx34J5tuOQPYYAE8Yl28aYtpGiLaDegz7FnBP29jENI6Rny5ndabWvWu1Rq33RWqKfDm8sbsTuGDxILP2LQx-yh9AnmPyQj5hQQqjGFEztsacYiq78EJYnTHaLEOatfetT5X8WTY51</recordid><startdate>199810</startdate><enddate>199810</enddate><creator>Muller, Jorg C.</creator><creator>Buhrer, Christoph</creator><creator>Kiening, Karl L.</creator><creator>Kerner, Thoralf</creator><creator>Gerlach, Herwig</creator><creator>Obladen, Michael</creator><creator>Unterberg, Andreas W.</creator><creator>Lanksch, Wolfgang R.</creator><general>Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199810</creationdate><title>Decreased Soluble Adhesion Molecule L-Selectin Plasma Concentrations after Major Trauma</title><author>Muller, Jorg C. ; Buhrer, Christoph ; Kiening, Karl L. ; Kerner, Thoralf ; Gerlach, Herwig ; Obladen, Michael ; Unterberg, Andreas W. ; Lanksch, Wolfgang R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3843-4f680f0078f940f980ebb49e6b0409ad416bd1bb50e9a0c8ed84b21ba7880f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Craniocerebral Trauma - blood</topic><topic>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>L-Selectin - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Trauma - blood</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><toplevel>online_resources</toplevel><creatorcontrib>Muller, Jorg C.</creatorcontrib><creatorcontrib>Buhrer, Christoph</creatorcontrib><creatorcontrib>Kiening, Karl L.</creatorcontrib><creatorcontrib>Kerner, Thoralf</creatorcontrib><creatorcontrib>Gerlach, Herwig</creatorcontrib><creatorcontrib>Obladen, Michael</creatorcontrib><creatorcontrib>Unterberg, Andreas W.</creatorcontrib><creatorcontrib>Lanksch, Wolfgang R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of Trauma: Injury, Infection, and Critical Care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muller, Jorg C.</au><au>Buhrer, Christoph</au><au>Kiening, Karl L.</au><au>Kerner, Thoralf</au><au>Gerlach, Herwig</au><au>Obladen, Michael</au><au>Unterberg, Andreas W.</au><au>Lanksch, Wolfgang R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Soluble Adhesion Molecule L-Selectin Plasma Concentrations after Major Trauma</atitle><jtitle>The Journal of Trauma: Injury, Infection, and Critical Care</jtitle><addtitle>J Trauma</addtitle><date>1998-10</date><risdate>1998</risdate><volume>45</volume><issue>4</issue><spage>705</spage><epage>708</epage><pages>705-708</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><coden>JOTRA5</coden><abstract>BACKGROUNDBinding of the leukocyte glycoprotein L-selectin to ligands expressed by activated endothelium directs leukocyte recruitment to areas of acute inflammation. Sequestration by activated microvascular endothelium has been proposed to explain the low plasma concentrations of soluble L-selectin (sCD62L) observed early in patients with acute respiratory distress syndrome. We hypothesized that inflammatory endothelial activation may occur in trauma patients, leading to decreased sCD62L plasma concentrations.
METHODSThis study was a prospective analysis of sCD62L plasma concentrations in patients with isolated head injuries and multiple trauma patients without head injuries admitted to two tertiary-level intensive care units. sCD62L plasma concentrations were determined in 18 consecutive adult patients with isolated moderate and severe head injuries and in 13 multiple trauma patients without head injuries immediately upon admission to the intensive care unit and then daily for up to 10 days after trauma.
RESULTSCompared with healthy adult controls (n = 22), patient sCD62L plasma concentrations were significantly decreased upon admission (5.7 +/- 1.6 vs. 11.0 +/- 1.7 pmol/mL; p < 0.001). In all patients, sCD62L concentrations remained depressed throughout the study period. sCD62L concentrations did not differ significantly between patients with isolated head injuries and multiple trauma patients without head injuries, although repeated-measures analysis of variance showed significantly more depressed sCD62L concentrations associated with severe (n = 14) compared with moderate head injuries (n = 4) during the study period (p < 0.05).
CONCLUSIONPatients with major trauma present with a significant reduction of sCD62L plasma concentrations within the first 12 hours after trauma and during subsequent intensive care. This finding suggests widespread microvascular endothelial activation after trauma, which may be associated with increased neutrophil extravasation.</abstract><cop>Baltimore, MD</cop><pub>Williams & Wilkins</pub><pmid>9783608</pmid><doi>10.1097/00005373-199810000-00013</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Craniocerebral Trauma - blood Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine Humans Intensive care medicine L-Selectin - blood Medical sciences Middle Aged Multiple Trauma - blood Prospective Studies Reference Values |
| title | Decreased Soluble Adhesion Molecule L-Selectin Plasma Concentrations after Major Trauma |
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