A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip
Background Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities. Methods The results of 90 patien...
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| Veröffentlicht in: | Head & neck 1999-09, Vol.21 (6), p.526-530 |
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| creator | de Visscher, Jan G.A.M. Botke, Gerrit Schakenraad, Jos A.C.M. van der Waal, Isaäc |
| description | Background
Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities.
Methods
The results of 90 patients who received radiotherapy and 166 patients who underwent surgery as the primary form of treatment for their stage I primary squamous cell carcinoma of the lower lip were evaluated. Tumor size and histological grade of differentiation were assessed.
Results
Local control rates were the same with radiotherapy or surgery. Overall survival rates for both groups of patients were similar as well. Disease‐free survival rates in the patients who underwent radiotherapy were significantly lower compared with the surgically treated group. This was due to a higher occurrence of regional metastases in the patients who received radiotherapy. Univariate analysis showed that irradiated patients had a statistically significant greater tumor size. The difference of histological differentiation between the groups was also statistically significant, the poorly differentiated being more common in the irradiated group. Multivariate analysis showed that only tumor size carried significant independent prognostic information.
Conclusions
The cure rates of stage I squamous cell carcinoma of the lower lip are favorable whether treated by radiotherapy or surgery, and local control rates are similar. The radiotherapeutic treated group showed an increased incidence of cervical metastases, which was due to the more advanced tumor size in these patients. © 1999 John Wiley & Sons, Inc. Head Neck 21: 526–530, 1999. |
| doi_str_mv | 10.1002/(SICI)1097-0347(199909)21:6<526::AID-HED5>3.0.CO;2-B |
| format | Article |
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Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities.
Methods
The results of 90 patients who received radiotherapy and 166 patients who underwent surgery as the primary form of treatment for their stage I primary squamous cell carcinoma of the lower lip were evaluated. Tumor size and histological grade of differentiation were assessed.
Results
Local control rates were the same with radiotherapy or surgery. Overall survival rates for both groups of patients were similar as well. Disease‐free survival rates in the patients who underwent radiotherapy were significantly lower compared with the surgically treated group. This was due to a higher occurrence of regional metastases in the patients who received radiotherapy. Univariate analysis showed that irradiated patients had a statistically significant greater tumor size. The difference of histological differentiation between the groups was also statistically significant, the poorly differentiated being more common in the irradiated group. Multivariate analysis showed that only tumor size carried significant independent prognostic information.
Conclusions
The cure rates of stage I squamous cell carcinoma of the lower lip are favorable whether treated by radiotherapy or surgery, and local control rates are similar. The radiotherapeutic treated group showed an increased incidence of cervical metastases, which was due to the more advanced tumor size in these patients. © 1999 John Wiley & Sons, Inc. Head Neck 21: 526–530, 1999.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/(SICI)1097-0347(199909)21:6<526::AID-HED5>3.0.CO;2-B</identifier><identifier>PMID: 10449668</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Carcinoma, Squamous Cell - therapy ; Chi-Square Distribution ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Lip Neoplasms - pathology ; Lip Neoplasms - radiotherapy ; Lip Neoplasms - surgery ; Lip Neoplasms - therapy ; lower lip ; Lymph Node Excision ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoadjuvant Therapy ; Neoplasm Staging ; Neoplasms, Second Primary - pathology ; Otorhinolaryngology. Stomatology ; Prognosis ; Proportional Hazards Models ; radiotherapy ; Retrospective Studies ; squamous cell carcinoma ; stage I ; surgery ; Survival Rate ; Treatment Outcome ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 1999-09, Vol.21 (6), p.526-530</ispartof><rights>Copyright © 1999 John Wiley & Sons, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 John Wiley & Sons, Inc. Head Neck 21: 526-530, 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4285-6ef7ea50de3d1989a71c18071a7fdbb43994b62121c789aa739f2384918e735c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0347%28199909%2921%3A6%3C526%3A%3AAID-HED5%3E3.0.CO%3B2-B$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0347%28199909%2921%3A6%3C526%3A%3AAID-HED5%3E3.0.CO%3B2-B$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1929946$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10449668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Visscher, Jan G.A.M.</creatorcontrib><creatorcontrib>Botke, Gerrit</creatorcontrib><creatorcontrib>Schakenraad, Jos A.C.M.</creatorcontrib><creatorcontrib>van der Waal, Isaäc</creatorcontrib><title>A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities.
Methods
The results of 90 patients who received radiotherapy and 166 patients who underwent surgery as the primary form of treatment for their stage I primary squamous cell carcinoma of the lower lip were evaluated. Tumor size and histological grade of differentiation were assessed.
Results
Local control rates were the same with radiotherapy or surgery. Overall survival rates for both groups of patients were similar as well. Disease‐free survival rates in the patients who underwent radiotherapy were significantly lower compared with the surgically treated group. This was due to a higher occurrence of regional metastases in the patients who received radiotherapy. Univariate analysis showed that irradiated patients had a statistically significant greater tumor size. The difference of histological differentiation between the groups was also statistically significant, the poorly differentiated being more common in the irradiated group. Multivariate analysis showed that only tumor size carried significant independent prognostic information.
Conclusions
The cure rates of stage I squamous cell carcinoma of the lower lip are favorable whether treated by radiotherapy or surgery, and local control rates are similar. The radiotherapeutic treated group showed an increased incidence of cervical metastases, which was due to the more advanced tumor size in these patients. © 1999 John Wiley & Sons, Inc. Head Neck 21: 526–530, 1999.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chi-Square Distribution</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lip Neoplasms - pathology</subject><subject>Lip Neoplasms - radiotherapy</subject><subject>Lip Neoplasms - surgery</subject><subject>Lip Neoplasms - therapy</subject><subject>lower lip</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>radiotherapy</subject><subject>Retrospective Studies</subject><subject>squamous cell carcinoma</subject><subject>stage I</subject><subject>surgery</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtv1DAQhSMEoqXwF5AfEGofsviS2PFSIW2z3TZQsQ8UVerLyOs4JW1utROV_fc4ZNUigcSTbc2Zb47nBMExwTOCMf1w-C1LsyOCpQgxi8QhkVJieUTJnB_HlM_ni2wZnp8u409shmfp-iMNT54F-48Nz8d7xEKGRbQXvHLuFmPMeERfBnu-EEnOk_3gboF0W3fKlq5tUFsga9xQ9Q6pojcWWZWXbf_DWNVtkWpy5AZ7Y-wWFa1Frlc3BmXI3Q-qbgeHtKkqpJXVZdPWaqT5VlS1D55Uld3r4EWhKmfe7M6D4Pvq9DI9Dy_WZ1m6uAh1RJM45KYQRsU4NywnMpFKEE0SLIgSRb7ZREzKaMMpoUQLX1WCyYKyJJIkMYLFmh0E7yduZ9v7wbge6tKN3lRjvE3gUoqIEuGFl5NQ29Y5awrobFkruwWCYQwBYAwBxp3CuFOYQgBKgIMPAcCHAGMIwABDugYKJx77djd_2NQm_wM6bd0L3u0EymlVFVY1unRPOkn9F_mTvYeyMtu_vP3H2j-c_X57bDhhS9ebn49YZe-ACyZiuPp6BqvPX8j19eoKluwXpDO9gA</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>de Visscher, Jan G.A.M.</creator><creator>Botke, Gerrit</creator><creator>Schakenraad, Jos A.C.M.</creator><creator>van der Waal, Isaäc</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip</title><author>de Visscher, Jan G.A.M. ; Botke, Gerrit ; Schakenraad, Jos A.C.M. ; van der Waal, Isaäc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4285-6ef7ea50de3d1989a71c18071a7fdbb43994b62121c789aa739f2384918e735c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chi-Square Distribution</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lip Neoplasms - pathology</topic><topic>Lip Neoplasms - radiotherapy</topic><topic>Lip Neoplasms - surgery</topic><topic>Lip Neoplasms - therapy</topic><topic>lower lip</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>radiotherapy</topic><topic>Retrospective Studies</topic><topic>squamous cell carcinoma</topic><topic>stage I</topic><topic>surgery</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Visscher, Jan G.A.M.</creatorcontrib><creatorcontrib>Botke, Gerrit</creatorcontrib><creatorcontrib>Schakenraad, Jos A.C.M.</creatorcontrib><creatorcontrib>van der Waal, Isaäc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Visscher, Jan G.A.M.</au><au>Botke, Gerrit</au><au>Schakenraad, Jos A.C.M.</au><au>van der Waal, Isaäc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1999-09</date><risdate>1999</risdate><volume>21</volume><issue>6</issue><spage>526</spage><epage>530</epage><pages>526-530</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities.
Methods
The results of 90 patients who received radiotherapy and 166 patients who underwent surgery as the primary form of treatment for their stage I primary squamous cell carcinoma of the lower lip were evaluated. Tumor size and histological grade of differentiation were assessed.
Results
Local control rates were the same with radiotherapy or surgery. Overall survival rates for both groups of patients were similar as well. Disease‐free survival rates in the patients who underwent radiotherapy were significantly lower compared with the surgically treated group. This was due to a higher occurrence of regional metastases in the patients who received radiotherapy. Univariate analysis showed that irradiated patients had a statistically significant greater tumor size. The difference of histological differentiation between the groups was also statistically significant, the poorly differentiated being more common in the irradiated group. Multivariate analysis showed that only tumor size carried significant independent prognostic information.
Conclusions
The cure rates of stage I squamous cell carcinoma of the lower lip are favorable whether treated by radiotherapy or surgery, and local control rates are similar. The radiotherapeutic treated group showed an increased incidence of cervical metastases, which was due to the more advanced tumor size in these patients. © 1999 John Wiley & Sons, Inc. Head Neck 21: 526–530, 1999.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10449668</pmid><doi>10.1002/(SICI)1097-0347(199909)21:6<526::AID-HED5>3.0.CO;2-B</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Carcinoma, Squamous Cell - therapy Chi-Square Distribution Disease-Free Survival Female Follow-Up Studies Humans Lip Neoplasms - pathology Lip Neoplasms - radiotherapy Lip Neoplasms - surgery Lip Neoplasms - therapy lower lip Lymph Node Excision Lymphatic Metastasis - pathology Male Medical sciences Middle Aged Multivariate Analysis Neoadjuvant Therapy Neoplasm Staging Neoplasms, Second Primary - pathology Otorhinolaryngology. Stomatology Prognosis Proportional Hazards Models radiotherapy Retrospective Studies squamous cell carcinoma stage I surgery Survival Rate Treatment Outcome Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip |
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