Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy
Background/Aim: Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF...
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| Veröffentlicht in: | Journal of hepatology 1999-08, Vol.31 (2), p.271-276 |
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| container_title | Journal of hepatology |
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| creator | Inaba, Tsuyoshi Saito, Hideaki Inoue, Tomomi Han, Ilsoo Furukawa, Satoshi Matsuda, Takeaki Ikeda, Shigeo Muto, Tetsuichiro |
| description | Background/Aim: Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF-1 axis alteration in cirrhosis to postoperative nitrogen metabolism are not known.
Methods: Plasma GH, IGF-1 and IGF binding protein 3 (IGF-BP3) levels were measured sequentially in patients undergoing hepatectomy with or without cirrhosis. Postoperative nitrogen excretion and wholebody protein turnover rate were also determined.
Results: Preoperative plasma IGF-1 level showed a negative correlation with indocyanine green retention rate. Cirrhosis patients undergoing hepatectomy had low IGF-1 and IGF-BP3 levels, despite extremely high GH levels in the perioperative period. Perioperative IGF-1 levels were lower in patients with postoperative complications than in those without complications. Postoperative nitrogen excretion was higher and wholebody protein turnover rate was lower in patients with cirrhosis than in those without cirrhosis. The postoperative IGF-1 level showed a positive correlation with whole-body protein turnover rate.
Conclusions: Postoperative hepatic IGF-1 production may be severely disturbed in patients with cirrhosis, and the impaired IGF-1 production contributes to the suppressed postoperative protein metabolism in cirrhosis. It may be appropriate to increase plasma IGF-1 level in patients with cirrhosis to enhance postoperative protein metabolism and improve the postoperative outcome. |
| doi_str_mv | 10.1016/S0168-8278(99)80224-4 |
| format | Article |
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Methods: Plasma GH, IGF-1 and IGF binding protein 3 (IGF-BP3) levels were measured sequentially in patients undergoing hepatectomy with or without cirrhosis. Postoperative nitrogen excretion and wholebody protein turnover rate were also determined.
Results: Preoperative plasma IGF-1 level showed a negative correlation with indocyanine green retention rate. Cirrhosis patients undergoing hepatectomy had low IGF-1 and IGF-BP3 levels, despite extremely high GH levels in the perioperative period. Perioperative IGF-1 levels were lower in patients with postoperative complications than in those without complications. Postoperative nitrogen excretion was higher and wholebody protein turnover rate was lower in patients with cirrhosis than in those without cirrhosis. The postoperative IGF-1 level showed a positive correlation with whole-body protein turnover rate.
Conclusions: Postoperative hepatic IGF-1 production may be severely disturbed in patients with cirrhosis, and the impaired IGF-1 production contributes to the suppressed postoperative protein metabolism in cirrhosis. It may be appropriate to increase plasma IGF-1 level in patients with cirrhosis to enhance postoperative protein metabolism and improve the postoperative outcome.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(99)80224-4</identifier><identifier>PMID: 10453940</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Aged ; Biological and medical sciences ; Cirrhosis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Growth hormone ; Hepatectomy ; Human Growth Hormone - blood ; Humans ; Insulin-like growth factor 1 ; Insulin-like growth factor binding protein 3 ; Insulin-Like Growth Factor Binding Protein 3 - biosynthesis ; Insulin-Like Growth Factor I - biosynthesis ; Liver Cirrhosis - blood ; Liver Cirrhosis - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Nitrogen - urine ; Nitrogen metabolism ; Other diseases. Semiology ; Proteins - metabolism ; Radioimmunoassay ; Survival Analysis</subject><ispartof>Journal of hepatology, 1999-08, Vol.31 (2), p.271-276</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-cdcbf8375b47fa0439c87404cfe06082f2e577f327d2da4d8628b30170110a2a3</citedby><cites>FETCH-LOGICAL-c390t-cdcbf8375b47fa0439c87404cfe06082f2e577f327d2da4d8628b30170110a2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168827899802244$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1921689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10453940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inaba, Tsuyoshi</creatorcontrib><creatorcontrib>Saito, Hideaki</creatorcontrib><creatorcontrib>Inoue, Tomomi</creatorcontrib><creatorcontrib>Han, Ilsoo</creatorcontrib><creatorcontrib>Furukawa, Satoshi</creatorcontrib><creatorcontrib>Matsuda, Takeaki</creatorcontrib><creatorcontrib>Ikeda, Shigeo</creatorcontrib><creatorcontrib>Muto, Tetsuichiro</creatorcontrib><title>Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background/Aim: Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF-1 axis alteration in cirrhosis to postoperative nitrogen metabolism are not known.
Methods: Plasma GH, IGF-1 and IGF binding protein 3 (IGF-BP3) levels were measured sequentially in patients undergoing hepatectomy with or without cirrhosis. Postoperative nitrogen excretion and wholebody protein turnover rate were also determined.
Results: Preoperative plasma IGF-1 level showed a negative correlation with indocyanine green retention rate. Cirrhosis patients undergoing hepatectomy had low IGF-1 and IGF-BP3 levels, despite extremely high GH levels in the perioperative period. Perioperative IGF-1 levels were lower in patients with postoperative complications than in those without complications. Postoperative nitrogen excretion was higher and wholebody protein turnover rate was lower in patients with cirrhosis than in those without cirrhosis. The postoperative IGF-1 level showed a positive correlation with whole-body protein turnover rate.
Conclusions: Postoperative hepatic IGF-1 production may be severely disturbed in patients with cirrhosis, and the impaired IGF-1 production contributes to the suppressed postoperative protein metabolism in cirrhosis. It may be appropriate to increase plasma IGF-1 level in patients with cirrhosis to enhance postoperative protein metabolism and improve the postoperative outcome.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cirrhosis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Growth hormone</subject><subject>Hepatectomy</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin-like growth factor 1</subject><subject>Insulin-like growth factor binding protein 3</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - biosynthesis</subject><subject>Insulin-Like Growth Factor I - biosynthesis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrogen - urine</subject><subject>Nitrogen metabolism</subject><subject>Other diseases. Semiology</subject><subject>Proteins - metabolism</subject><subject>Radioimmunoassay</subject><subject>Survival Analysis</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFSEUhonR2Gv1ETQsjNHF2APDHYZVY5pamzRxoa4Jwxy86AxcgdH2KXxlaefGunMD4fD9_zn5DyHPGbxlwLqTT_Xom57L_rVSb3rgXDTiAdmwDqCBTrCHZPMXOSJPcv4GAC0o8ZgcMRDbVgnYkN8XKf4qO7qLaY4BT3zIy-RDM_nvSL-uf87YEhNl1Fz7TM1UMJniY8jUxlCSH5aCtEQ6-lyWNOBI9ykW9IHOWMwQJ59nWl_Wp7SLuXrsqx5DqWaumtEd1gLWJvPNU_LImSnjs8N9TL68P_989qG5-nhxefbuqrGtgtLY0Q6ub-V2ENIZEK2yvRQgrEPooOeO41ZK13I58tGIse94P7TAJDAGhpv2mLxafeuoPxbMRc8-W5wmEzAuWXdKyaqWFdyuoE0x54RO75OfTbrRDPTtJvTdJvRtzFopfbcJLaruxaHBMsw4_qNao6_AywNgsjWTSyZYn-85xautqtjpimFN46fHpLOt2VkcfaqR6TH6_0zyBzj0qO4</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Inaba, Tsuyoshi</creator><creator>Saito, Hideaki</creator><creator>Inoue, Tomomi</creator><creator>Han, Ilsoo</creator><creator>Furukawa, Satoshi</creator><creator>Matsuda, Takeaki</creator><creator>Ikeda, Shigeo</creator><creator>Muto, Tetsuichiro</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy</title><author>Inaba, Tsuyoshi ; Saito, Hideaki ; Inoue, Tomomi ; Han, Ilsoo ; Furukawa, Satoshi ; Matsuda, Takeaki ; Ikeda, Shigeo ; Muto, Tetsuichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-cdcbf8375b47fa0439c87404cfe06082f2e577f327d2da4d8628b30170110a2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cirrhosis</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Growth hormone</topic><topic>Hepatectomy</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin-like growth factor 1</topic><topic>Insulin-like growth factor binding protein 3</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - biosynthesis</topic><topic>Insulin-Like Growth Factor I - biosynthesis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitrogen - urine</topic><topic>Nitrogen metabolism</topic><topic>Other diseases. Semiology</topic><topic>Proteins - metabolism</topic><topic>Radioimmunoassay</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inaba, Tsuyoshi</creatorcontrib><creatorcontrib>Saito, Hideaki</creatorcontrib><creatorcontrib>Inoue, Tomomi</creatorcontrib><creatorcontrib>Han, Ilsoo</creatorcontrib><creatorcontrib>Furukawa, Satoshi</creatorcontrib><creatorcontrib>Matsuda, Takeaki</creatorcontrib><creatorcontrib>Ikeda, Shigeo</creatorcontrib><creatorcontrib>Muto, Tetsuichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inaba, Tsuyoshi</au><au>Saito, Hideaki</au><au>Inoue, Tomomi</au><au>Han, Ilsoo</au><au>Furukawa, Satoshi</au><au>Matsuda, Takeaki</au><au>Ikeda, Shigeo</au><au>Muto, Tetsuichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>31</volume><issue>2</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background/Aim: Liver cirrhosis is accompanied by a fall in whole-body protein turnover and alterations of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. However, the influence of liver cirrhosis on the GH/IGF-1 axis in the perioperative period, and the contribution of the GH/IGF-1 axis alteration in cirrhosis to postoperative nitrogen metabolism are not known.
Methods: Plasma GH, IGF-1 and IGF binding protein 3 (IGF-BP3) levels were measured sequentially in patients undergoing hepatectomy with or without cirrhosis. Postoperative nitrogen excretion and wholebody protein turnover rate were also determined.
Results: Preoperative plasma IGF-1 level showed a negative correlation with indocyanine green retention rate. Cirrhosis patients undergoing hepatectomy had low IGF-1 and IGF-BP3 levels, despite extremely high GH levels in the perioperative period. Perioperative IGF-1 levels were lower in patients with postoperative complications than in those without complications. Postoperative nitrogen excretion was higher and wholebody protein turnover rate was lower in patients with cirrhosis than in those without cirrhosis. The postoperative IGF-1 level showed a positive correlation with whole-body protein turnover rate.
Conclusions: Postoperative hepatic IGF-1 production may be severely disturbed in patients with cirrhosis, and the impaired IGF-1 production contributes to the suppressed postoperative protein metabolism in cirrhosis. It may be appropriate to increase plasma IGF-1 level in patients with cirrhosis to enhance postoperative protein metabolism and improve the postoperative outcome.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>10453940</pmid><doi>10.1016/S0168-8278(99)80224-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of hepatology, 1999-08, Vol.31 (2), p.271-276 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| subjects | Aged Biological and medical sciences Cirrhosis Female Gastroenterology. Liver. Pancreas. Abdomen Growth hormone Hepatectomy Human Growth Hormone - blood Humans Insulin-like growth factor 1 Insulin-like growth factor binding protein 3 Insulin-Like Growth Factor Binding Protein 3 - biosynthesis Insulin-Like Growth Factor I - biosynthesis Liver Cirrhosis - blood Liver Cirrhosis - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Nitrogen - urine Nitrogen metabolism Other diseases. Semiology Proteins - metabolism Radioimmunoassay Survival Analysis |
| title | Growth hormone/insulin-like growth factor 1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy |
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