Differentiation Markers and Invasiveness: Discordant Regulation in Normal Trophoblast and Choriocarcinoma Cells

In tumor cells, malignant (invasive) behavior and differentiation tend to be correlated inversely, although it is not clear to what extent this can be generalized and whether it may also apply to normal invasive cell types. We have modulated differentiation of normal trophoblast cells from first tri...

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