Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils
We studied whether eugenol provides neuroprotection against delayed neuronal death in the hippocampal CA1 region following a 5 min occlusion of the common carotid arteries bilaterally under either free-regulating temperature (TF) or maintained temperature (TM, 37ºC) conditions in gerbils. Right afte...
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| Veröffentlicht in: | Neuroscience letters 1998-09, Vol.254 (2), p.101-104 |
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| container_title | Neuroscience letters |
| container_volume | 254 |
| creator | Won, Moo Ho Lee, Jae Chul Kim, Yung Hi Song, Dong Keun Suh, Hong Won Oh, Yang Seok Kim, Jung Hoon Shin, Tae kyun Lee, Young Jae Wie, Myung Bok |
| description | We studied whether eugenol provides neuroprotection against delayed neuronal death in the hippocampal CA1 region following a 5 min occlusion of the common carotid arteries bilaterally under either free-regulating temperature (TF) or maintained temperature (TM, 37ºC) conditions in gerbils. Right after occlusion of the carotid arteries, we injected eugenol intraperitoneally at concentrations of either 50, 100, or 200 mg/kg. There was significant preservation of neuronal cells in the CA1 region in the eugenol-treated groups 7 days after the ischemic insult in the TF condition, with respective survival values of 26, 43, and 68%. In the TM condition, however, significant neuroprotection was only seen with eugenol concentrations of 100 and 200 mg/kg (32% and 52%, respectively). When the rectal temperature was maintained at 38ºC for 30 min after occlusion of the carotid arteries, no reduction in CA1 damage was observed with any dose of eugenol. These results suggest that eugenol may provide neuroprotection against ischemic damage by its hypothermic action. |
| doi_str_mv | 10.1016/S0304-3940(98)00664-8 |
| format | Article |
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Right after occlusion of the carotid arteries, we injected eugenol intraperitoneally at concentrations of either 50, 100, or 200 mg/kg. There was significant preservation of neuronal cells in the CA1 region in the eugenol-treated groups 7 days after the ischemic insult in the TF condition, with respective survival values of 26, 43, and 68%. In the TM condition, however, significant neuroprotection was only seen with eugenol concentrations of 100 and 200 mg/kg (32% and 52%, respectively). When the rectal temperature was maintained at 38ºC for 30 min after occlusion of the carotid arteries, no reduction in CA1 damage was observed with any dose of eugenol. These results suggest that eugenol may provide neuroprotection against ischemic damage by its hypothermic action.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(98)00664-8</identifier><identifier>PMID: 9779930</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Body Temperature - physiology ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Dose-Response Relationship, Drug ; Eugenol ; Eugenol - therapeutic use ; Gerbillinae ; Global ischemia ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - pathology ; Hypothermia ; Hypothermia, Induced ; Male ; Medical sciences ; Mongolian gerbil ; Neurons - drug effects ; Neurons - pathology ; Neuropharmacology ; Neuroprotection ; Neuroprotective agent ; Neuroprotective Agents - therapeutic use ; Osmolar Concentration ; Pharmacology. Drug treatments</subject><ispartof>Neuroscience letters, 1998-09, Vol.254 (2), p.101-104</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-80d343eecc7ba253036632ba61440e3cf7bceeabc11623d045b4f6e6ab6aabd63</citedby><cites>FETCH-LOGICAL-c538t-80d343eecc7ba253036632ba61440e3cf7bceeabc11623d045b4f6e6ab6aabd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(98)00664-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2422855$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9779930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Won, Moo Ho</creatorcontrib><creatorcontrib>Lee, Jae Chul</creatorcontrib><creatorcontrib>Kim, Yung Hi</creatorcontrib><creatorcontrib>Song, Dong Keun</creatorcontrib><creatorcontrib>Suh, Hong Won</creatorcontrib><creatorcontrib>Oh, Yang Seok</creatorcontrib><creatorcontrib>Kim, Jung Hoon</creatorcontrib><creatorcontrib>Shin, Tae kyun</creatorcontrib><creatorcontrib>Lee, Young Jae</creatorcontrib><creatorcontrib>Wie, Myung Bok</creatorcontrib><title>Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We studied whether eugenol provides neuroprotection against delayed neuronal death in the hippocampal CA1 region following a 5 min occlusion of the common carotid arteries bilaterally under either free-regulating temperature (TF) or maintained temperature (TM, 37ºC) conditions in gerbils. Right after occlusion of the carotid arteries, we injected eugenol intraperitoneally at concentrations of either 50, 100, or 200 mg/kg. There was significant preservation of neuronal cells in the CA1 region in the eugenol-treated groups 7 days after the ischemic insult in the TF condition, with respective survival values of 26, 43, and 68%. In the TM condition, however, significant neuroprotection was only seen with eugenol concentrations of 100 and 200 mg/kg (32% and 52%, respectively). When the rectal temperature was maintained at 38ºC for 30 min after occlusion of the carotid arteries, no reduction in CA1 damage was observed with any dose of eugenol. These results suggest that eugenol may provide neuroprotection against ischemic damage by its hypothermic action.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Temperature - physiology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Brain Ischemia - therapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eugenol</subject><subject>Eugenol - therapeutic use</subject><subject>Gerbillinae</subject><subject>Global ischemia</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mongolian gerbil</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Neuropharmacology</subject><subject>Neuroprotection</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Osmolar Concentration</subject><subject>Pharmacology. Drug treatments</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAUhUVpSKdpf0JAi1LahVu9Za9KCH1BIIG2ayHJ12MV23IluzD_PpqMmW1Wgnu_e3Q4B6FrSj5RQtXnX4QTUfFGkA9N_ZEQpURVv0A7WmtW6Uazl2h3Rl6h1zn_JYRIKsUlumy0bhpOdqh_iHkJ2fcwBo_7wxyXHtIYLA5Tu3posTtgWPcwxQHPKS7gl4z7MM_R23G2A55gTXHKuEtxxPshujLbBI8ieA_JhSG_QRedHTK83d4r9Ofb19-3P6q7--8_b2_uKi95vVQ1abngAN5rZ5nkhCvFmbOKCkGA-047D2Cdp1Qx3hIhnegUKOuUta5V_Aq9P-kWs_9WyIsZixsYBjtBXLNRTYlGSf0sSDVtBNO0gPIE-hRzTtCZOYXRpoOhxByrME9VmGPOpqnNUxWmLnfX2werG6E9X23Zl_27bW-zt0OX7ORDPmNMMFZLWbAvJwxKav8DJJN9gKlUE1Ipw7QxPGPkEXeLp9s</recordid><startdate>19980925</startdate><enddate>19980925</enddate><creator>Won, Moo Ho</creator><creator>Lee, Jae Chul</creator><creator>Kim, Yung Hi</creator><creator>Song, Dong Keun</creator><creator>Suh, Hong Won</creator><creator>Oh, Yang Seok</creator><creator>Kim, Jung Hoon</creator><creator>Shin, Tae kyun</creator><creator>Lee, Young Jae</creator><creator>Wie, Myung Bok</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980925</creationdate><title>Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils</title><author>Won, Moo Ho ; Lee, Jae Chul ; Kim, Yung Hi ; Song, Dong Keun ; Suh, Hong Won ; Oh, Yang Seok ; Kim, Jung Hoon ; Shin, Tae kyun ; Lee, Young Jae ; Wie, Myung Bok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-80d343eecc7ba253036632ba61440e3cf7bceeabc11623d045b4f6e6ab6aabd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Body Temperature - physiology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Brain Ischemia - therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eugenol</topic><topic>Eugenol - therapeutic use</topic><topic>Gerbillinae</topic><topic>Global ischemia</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mongolian gerbil</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Neuropharmacology</topic><topic>Neuroprotection</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Osmolar Concentration</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won, Moo Ho</creatorcontrib><creatorcontrib>Lee, Jae Chul</creatorcontrib><creatorcontrib>Kim, Yung Hi</creatorcontrib><creatorcontrib>Song, Dong Keun</creatorcontrib><creatorcontrib>Suh, Hong Won</creatorcontrib><creatorcontrib>Oh, Yang Seok</creatorcontrib><creatorcontrib>Kim, Jung Hoon</creatorcontrib><creatorcontrib>Shin, Tae kyun</creatorcontrib><creatorcontrib>Lee, Young Jae</creatorcontrib><creatorcontrib>Wie, Myung Bok</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won, Moo Ho</au><au>Lee, Jae Chul</au><au>Kim, Yung Hi</au><au>Song, Dong Keun</au><au>Suh, Hong Won</au><au>Oh, Yang Seok</au><au>Kim, Jung Hoon</au><au>Shin, Tae kyun</au><au>Lee, Young Jae</au><au>Wie, Myung Bok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1998-09-25</date><risdate>1998</risdate><volume>254</volume><issue>2</issue><spage>101</spage><epage>104</epage><pages>101-104</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>We studied whether eugenol provides neuroprotection against delayed neuronal death in the hippocampal CA1 region following a 5 min occlusion of the common carotid arteries bilaterally under either free-regulating temperature (TF) or maintained temperature (TM, 37ºC) conditions in gerbils. Right after occlusion of the carotid arteries, we injected eugenol intraperitoneally at concentrations of either 50, 100, or 200 mg/kg. There was significant preservation of neuronal cells in the CA1 region in the eugenol-treated groups 7 days after the ischemic insult in the TF condition, with respective survival values of 26, 43, and 68%. In the TM condition, however, significant neuroprotection was only seen with eugenol concentrations of 100 and 200 mg/kg (32% and 52%, respectively). When the rectal temperature was maintained at 38ºC for 30 min after occlusion of the carotid arteries, no reduction in CA1 damage was observed with any dose of eugenol. These results suggest that eugenol may provide neuroprotection against ischemic damage by its hypothermic action.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9779930</pmid><doi>10.1016/S0304-3940(98)00664-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1998-09, Vol.254 (2), p.101-104 |
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| subjects | Animals Biological and medical sciences Body Temperature - drug effects Body Temperature - physiology Brain Ischemia - physiopathology Brain Ischemia - therapy Dose-Response Relationship, Drug Eugenol Eugenol - therapeutic use Gerbillinae Global ischemia Hippocampus Hippocampus - drug effects Hippocampus - pathology Hypothermia Hypothermia, Induced Male Medical sciences Mongolian gerbil Neurons - drug effects Neurons - pathology Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - therapeutic use Osmolar Concentration Pharmacology. Drug treatments |
| title | Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils |
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