Evidence that Ca2+-activated K+ channels play a major role in mediating the vascular effects of iloprost and cicaprost

The role of K+ channels in mediating vasorelaxation induced by two prostacyclin analogues was investigated in guinea-pig aorta. Iloprost caused substantial relaxation of tissues contracted with phenylephrine or 25 mM K+ but not 60 mM K+. In endothelial-denuded tissues, maximal relaxations to ilopros...

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Veröffentlicht in:	European journal of pharmacology 1998-09, Vol.356 (2-3), p.215-224
Hauptverfasser:	CLAPP, L. H, TURCATO, S, HALL, S, BALOCH, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - antagonists & inhibitors Antineoplastic Agents - pharmacology Biological and medical sciences Calcium - metabolism Cardiovascular system Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Epoprostenol - analogs & derivatives Epoprostenol - antagonists & inhibitors Epoprostenol - pharmacology Guinea Pigs Hydrazines - pharmacology Iloprost - antagonists & inhibitors Iloprost - pharmacology Isoproterenol - antagonists & inhibitors Isoproterenol - pharmacology Male Medical sciences Muscle, Smooth, Vascular - drug effects Oxazepines - pharmacology Pharmacology. Drug treatments Phenylephrine - antagonists & inhibitors Potassium Channel Blockers Potassium Channels - drug effects Potassium Channels - physiology Prostaglandin Antagonists - pharmacology Tetraethylammonium - pharmacology Vasodilation - drug effects Vasodilator Agents - antagonists & inhibitors Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators
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