Splenectomy attenuates superoxide anion release into the hepatic sinusoids after lipopolysaccharide challenge

Background/Aims: The aim of this study was to determine whether the spleen contributes to superoxide anion release into the hepatic sinusoids and subsequent damage to endothelial cells of the hepatic sinusoids after lipopolysaccharide challenge. Methods: Rats were given 2 mg/kg body weight lipopolys...

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Veröffentlicht in:	Journal of hepatology 1999-08, Vol.31 (2), p.235-241
Hauptverfasser:	Mizukami, Takeshi, Yokoyama, Hirokazu, Okamura, Yukishige, Ohgo, Hideki, Fukuda, Masahiko, Kamegaya, Yoshitaka, Kato, Shinzo, Ishii, Hiromasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Capillaries - metabolism Capillaries - pathology Cytochrome C Cytochrome c Group Gastroenterology. Liver. Pancreas. Abdomen Hepatic macrophages Kupffer cells Kupffer Cells - metabolism Lipopolysaccharide Lipopolysaccharides - adverse effects Liver - metabolism Liver - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Macrophages - metabolism Male Medical sciences Other diseases. Semiology Rats Rats, Wistar Spleen - metabolism Splenectomy Superoxide anion Superoxides - metabolism
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