Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions
Many epidemiological studies suggest that use of non‐steroidal anti‐inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease (AD). While it has been demonstrated that neurodegeneration in AD is accompanied by specific inflammatory mechanisms, including activation...
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| Veröffentlicht in: | Journal of neuroscience research 1998-10, Vol.54 (1), p.1-6 |
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| description | Many epidemiological studies suggest that use of non‐steroidal anti‐inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease (AD). While it has been demonstrated that neurodegeneration in AD is accompanied by specific inflammatory mechanisms, including activation of the complement cascade and the accumulation and activation of microglia, the mechanism by which NSAIDs might affect these or other pathophysiological processes relevant to AD has been unclear. New evidence that cyclooxygenase (COX) is involved in neurodegeneration along with the development of selective COX inhibitors has led to renewed interest in the therapeutic potential of NSAIDs in AD. J. Neurosci. Res. 54:1–6, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-4547(19981001)54:1<1::AID-JNR1>3.0.CO;2-M |
| format | Article |
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Neurosci. Res</addtitle><description>Many epidemiological studies suggest that use of non‐steroidal anti‐inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease (AD). While it has been demonstrated that neurodegeneration in AD is accompanied by specific inflammatory mechanisms, including activation of the complement cascade and the accumulation and activation of microglia, the mechanism by which NSAIDs might affect these or other pathophysiological processes relevant to AD has been unclear. New evidence that cyclooxygenase (COX) is involved in neurodegeneration along with the development of selective COX inhibitors has led to renewed interest in the therapeutic potential of NSAIDs in AD. J. Neurosci. 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| identifier | ISSN: 0360-4012 |
| ispartof | Journal of neuroscience research, 1998-10, Vol.54 (1), p.1-6 |
| issn | 0360-4012 1097-4547 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Brain - metabolism Brain - pathology cyclooxygenase Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - therapeutic use Humans inflammation Inflammation - drug therapy Inflammation - pathology Isoenzymes - metabolism Membrane Proteins NSAIDs Oxidative Stress Prostaglandin-Endoperoxide Synthases - metabolism |
| title | Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions |
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