characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine
Summary Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result of ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins of resected small intestine from 9 horses with small inte...
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| Veröffentlicht in: | Equine veterinary journal 1999-07, Vol.31 (4), p.331-335 |
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| container_title | Equine veterinary journal |
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| creator | Gerard, M.P Blikslager, A.T Roberts, M.C Tate, L.P. Jr Argenzio, R.A |
| description | Summary
Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result of ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins of resected small intestine from 9 horses with small intestinal strangulating lesions were examined for evidence of ischaemia/reperfusion injury. Severe mucosal injury and marked elevations in myeloperoxidase activity were detected at ileal resection margins (n = 4), whereas the mucosa from proximal jejunal (n = 9) and distal jejunal (n = 5) resection margins was normal. However, the serosa from jejunal resection margins had evidence of haemorrhage and oedema, and the proximal jejunal serosa had significantly increased numbers of neutrophils. Histological injury in ileal stumps is indicative of the inability fully to resect the ileum in horses with distal small intestinal strangulations. One of 4 horses subjected to ileal resection was subjected to euthanasia and found to have a necrotic ileal stump. Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. Four of 8 horses discharged from the hospital suffered from recurrent colic in the post operative period. |
| doi_str_mv | 10.1111/j.2042-3306.1999.tb03826.x |
| format | Article |
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Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result of ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins of resected small intestine from 9 horses with small intestinal strangulating lesions were examined for evidence of ischaemia/reperfusion injury. Severe mucosal injury and marked elevations in myeloperoxidase activity were detected at ileal resection margins (n = 4), whereas the mucosa from proximal jejunal (n = 9) and distal jejunal (n = 5) resection margins was normal. However, the serosa from jejunal resection margins had evidence of haemorrhage and oedema, and the proximal jejunal serosa had significantly increased numbers of neutrophils. Histological injury in ileal stumps is indicative of the inability fully to resect the ileum in horses with distal small intestinal strangulations. One of 4 horses subjected to ileal resection was subjected to euthanasia and found to have a necrotic ileal stump. Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. Four of 8 horses discharged from the hospital suffered from recurrent colic in the post operative period.</description><identifier>ISSN: 0425-1644</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/j.2042-3306.1999.tb03826.x</identifier><identifier>PMID: 10454093</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anastomosis, Surgical - veterinary ; animal injuries ; Animals ; Follow-Up Studies ; horse ; Horse Diseases - etiology ; Horse Diseases - pathology ; Horse Diseases - surgery ; Horses ; intestinal mucosa ; Intestinal Mucosa - enzymology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; intestinal obstruction ; Intestinal Obstruction - complications ; Intestinal Obstruction - pathology ; Intestinal Obstruction - surgery ; Intestinal Obstruction - veterinary ; intestine ; Intestine, Small - metabolism ; Intestine, Small - pathology ; Intestine, Small - surgery ; ischaemia ; ischemia ; Lipid Peroxidation ; myeloperoxidase ; Peroxidase - metabolism ; peroxidases ; Reperfusion Injury - etiology ; Reperfusion Injury - pathology ; Reperfusion Injury - veterinary ; resection ; small intestine</subject><ispartof>Equine veterinary journal, 1999-07, Vol.31 (4), p.331-335</ispartof><rights>1999 EVJ Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4336-109c0d442a12f3cce90c61bc21b84c50d674cd3b135ca4b3dd7df0a51fada43f3</citedby><cites>FETCH-LOGICAL-c4336-109c0d442a12f3cce90c61bc21b84c50d674cd3b135ca4b3dd7df0a51fada43f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.2042-3306.1999.tb03826.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.2042-3306.1999.tb03826.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10454093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerard, M.P</creatorcontrib><creatorcontrib>Blikslager, A.T</creatorcontrib><creatorcontrib>Roberts, M.C</creatorcontrib><creatorcontrib>Tate, L.P. Jr</creatorcontrib><creatorcontrib>Argenzio, R.A</creatorcontrib><title>characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Summary
Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result of ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins of resected small intestine from 9 horses with small intestinal strangulating lesions were examined for evidence of ischaemia/reperfusion injury. Severe mucosal injury and marked elevations in myeloperoxidase activity were detected at ileal resection margins (n = 4), whereas the mucosa from proximal jejunal (n = 9) and distal jejunal (n = 5) resection margins was normal. However, the serosa from jejunal resection margins had evidence of haemorrhage and oedema, and the proximal jejunal serosa had significantly increased numbers of neutrophils. Histological injury in ileal stumps is indicative of the inability fully to resect the ileum in horses with distal small intestinal strangulations. One of 4 horses subjected to ileal resection was subjected to euthanasia and found to have a necrotic ileal stump. Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. Four of 8 horses discharged from the hospital suffered from recurrent colic in the post operative period.</description><subject>Anastomosis, Surgical - veterinary</subject><subject>animal injuries</subject><subject>Animals</subject><subject>Follow-Up Studies</subject><subject>horse</subject><subject>Horse Diseases - etiology</subject><subject>Horse Diseases - pathology</subject><subject>Horse Diseases - surgery</subject><subject>Horses</subject><subject>intestinal mucosa</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>intestinal obstruction</subject><subject>Intestinal Obstruction - complications</subject><subject>Intestinal Obstruction - pathology</subject><subject>Intestinal Obstruction - surgery</subject><subject>Intestinal Obstruction - veterinary</subject><subject>intestine</subject><subject>Intestine, Small - metabolism</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - surgery</subject><subject>ischaemia</subject><subject>ischemia</subject><subject>Lipid Peroxidation</subject><subject>myeloperoxidase</subject><subject>Peroxidase - metabolism</subject><subject>peroxidases</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - veterinary</subject><subject>resection</subject><subject>small intestine</subject><issn>0425-1644</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU2P0zAQhi0EYsvCXwCLA7dkbY_zYS4Iyn6AVqAVLBwtx3HaFDfp2olo__1OlKriii8zYz_zjvwOIW85Szmei00qmBQJAMtTrpRKh4pBKfJ0_4QsTk9PyQLTLOG5lGfkRYwbxgCEFM_JGWcyk0zBggS7NsHYwYU2Dq2NtG9o2w0Oi854TDdjONAdPu_WLuDN0NM4BNOtRm-QWdG-wnq0Q9t31LuIIWIbHdaOuoex7RyNW-P9SdW9JM8a46N7dYzn5P7q8ufyJrn9fv1l-fE2sRIgTzhTltVSCsNFA9Y6xWzOKyt4VUqbsTovpK2h4pBZIyuo66JumMl4Y2ojoYFz8m7W3YX-YcTZettG67w3nevHqHOlCsahRPD9DNrQxxhco3eh3Zpw0JzpyXG90ZOterJVT47ro-N6j82vj1PGauvqf1pnixH4MAN_W-8O_yGtL399nTJUSGYFXJHbnxRM-KPzAopM__52rZdXd-rT5_JO3yD_ZuYb02uzws3q-x8Cv8qEglKChEdFwa0t</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Gerard, M.P</creator><creator>Blikslager, A.T</creator><creator>Roberts, M.C</creator><creator>Tate, L.P. Jr</creator><creator>Argenzio, R.A</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine</title><author>Gerard, M.P ; Blikslager, A.T ; Roberts, M.C ; Tate, L.P. Jr ; Argenzio, R.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4336-109c0d442a12f3cce90c61bc21b84c50d674cd3b135ca4b3dd7df0a51fada43f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anastomosis, Surgical - veterinary</topic><topic>animal injuries</topic><topic>Animals</topic><topic>Follow-Up Studies</topic><topic>horse</topic><topic>Horse Diseases - etiology</topic><topic>Horse Diseases - pathology</topic><topic>Horse Diseases - surgery</topic><topic>Horses</topic><topic>intestinal mucosa</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>intestinal obstruction</topic><topic>Intestinal Obstruction - complications</topic><topic>Intestinal Obstruction - pathology</topic><topic>Intestinal Obstruction - surgery</topic><topic>Intestinal Obstruction - veterinary</topic><topic>intestine</topic><topic>Intestine, Small - metabolism</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - surgery</topic><topic>ischaemia</topic><topic>ischemia</topic><topic>Lipid Peroxidation</topic><topic>myeloperoxidase</topic><topic>Peroxidase - metabolism</topic><topic>peroxidases</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - veterinary</topic><topic>resection</topic><topic>small intestine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerard, M.P</creatorcontrib><creatorcontrib>Blikslager, A.T</creatorcontrib><creatorcontrib>Roberts, M.C</creatorcontrib><creatorcontrib>Tate, L.P. Jr</creatorcontrib><creatorcontrib>Argenzio, R.A</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerard, M.P</au><au>Blikslager, A.T</au><au>Roberts, M.C</au><au>Tate, L.P. Jr</au><au>Argenzio, R.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>1999-07</date><risdate>1999</risdate><volume>31</volume><issue>4</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>0425-1644</issn><eissn>2042-3306</eissn><abstract>Summary
Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result of ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins of resected small intestine from 9 horses with small intestinal strangulating lesions were examined for evidence of ischaemia/reperfusion injury. Severe mucosal injury and marked elevations in myeloperoxidase activity were detected at ileal resection margins (n = 4), whereas the mucosa from proximal jejunal (n = 9) and distal jejunal (n = 5) resection margins was normal. However, the serosa from jejunal resection margins had evidence of haemorrhage and oedema, and the proximal jejunal serosa had significantly increased numbers of neutrophils. Histological injury in ileal stumps is indicative of the inability fully to resect the ileum in horses with distal small intestinal strangulations. One of 4 horses subjected to ileal resection was subjected to euthanasia and found to have a necrotic ileal stump. Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. Four of 8 horses discharged from the hospital suffered from recurrent colic in the post operative period.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10454093</pmid><doi>10.1111/j.2042-3306.1999.tb03826.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anastomosis, Surgical - veterinary animal injuries Animals Follow-Up Studies horse Horse Diseases - etiology Horse Diseases - pathology Horse Diseases - surgery Horses intestinal mucosa Intestinal Mucosa - enzymology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology intestinal obstruction Intestinal Obstruction - complications Intestinal Obstruction - pathology Intestinal Obstruction - surgery Intestinal Obstruction - veterinary intestine Intestine, Small - metabolism Intestine, Small - pathology Intestine, Small - surgery ischaemia ischemia Lipid Peroxidation myeloperoxidase Peroxidase - metabolism peroxidases Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - veterinary resection small intestine |
| title | characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine |
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