p300/CREB-Binding Protein Enhances the Prolactin-Mediated Transcriptional Induction through Direct Interaction with the Transactivation Domain of Stat5, but Does Not Participate in the Stat5-Mediated Suppression of the Glucocorticoid Response

Stat5 was discovered as a PRL-induced member of the Stat (signal transducer and activator of transcription) family. Its induction by many other cytokines and interleukins suggests that Stat5 plays a crucial role not only in mammary epithelial, but also in hematopoietic cells. Cell type- and promoter...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 1998-10, Vol.12 (10), p.1582-1593
Hauptverfasser:	Pfitzner, Edith, Jähne, Ruth, Wissler, Manuela, Stoecklin, Elisabeth, Groner, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - drug effects Adenovirus E1A Proteins - genetics Adenovirus E1A Proteins - metabolism Animals Binding Sites COS Cells - drug effects Cricetinae Dexamethasone - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Glucocorticoids - metabolism Glucocorticoids - pharmacology HeLa Cells - drug effects HeLa Cells - metabolism Histone Acetyltransferases Humans Mammary Tumor Virus, Mouse - genetics Mice Milk Proteins Mouse mammary tumor virus Nuclear Receptor Coactivator 3 Phosphorylation Prolactin - metabolism Prolactin - pharmacology Promoter Regions, Genetic Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism STAT5 Transcription Factor Terminal Repeat Sequences Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation Tyrosine - metabolism
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