Serotonin enhances the production of type IV collagen by human mesangial cells

Serotonin enhances the production of type IV collagen by human mesangial cells. The plasma concentration of 5-hydroxytryptamine (5-HT) in diabetic patients is higher than that in normal subjects. Since recent reports have demonstrated the presence of 5-HT2A receptor in glomerular mesangial cells, it...

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Veröffentlicht in:	Kidney international 1998-10, Vol.54 (4), p.1083-1092
Hauptverfasser:	Kasho, Masaya, Sakai, Masakazu, Sasahara, Takayuki, Anami, Yoshichika, Matsumura, Takeshi, Takemura, Toru, Matsuda, Hirofumi, Kobori, Shozo, Shichiri, Motoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Collagen - biosynthesis Diabetic Nephropathies - etiology Diabetic Nephropathies - metabolism diabetic nephropathy Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism human mesangial cell Humans Investigative techniques, diagnostic techniques (general aspects) Ketanserin - pharmacology Kinetics Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques protein kinase C Protein Kinase C - metabolism Receptor, Serotonin, 5-HT2A Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism serotonin Serotonin - pharmacology Serotonin Antagonists - pharmacology Succinates - pharmacology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism transforming growth factor-β type IV collagen Urinary system
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