Role of Fe(III) in Fe(II)citrate-mediated peroxidation of mitochondrial membrane lipids

In this report we study the effect of Fe(III) on lipid peroxidation induced by Fe(II)citrate in mitochondrial membranes, as assessed by the production of thiobarbituric acid-reactive substances and antimycin A-insensitive oxygen uptake. The presence of Fe(III) stimulates initiation of lipid peroxida...

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Veröffentlicht in:	Molecular and cellular biochemistry 1999-06, Vol.196 (1/2), p.163-168
Hauptverfasser:	Castilho, R.F, Meinicke, A.R, Vercesi, A.E, Hermes-Lima, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals citrates Ferric Compounds - metabolism ferric ions Ferrous Compounds - metabolism ferrous ions free radicals Intracellular Membranes - metabolism Iron Lipid Peroxidation Lipids Membrane Lipids - metabolism Mitochondria - metabolism Oxygen Oxygen Consumption Oxygen uptake Peroxidation Rats Rats, Wistar reactive oxygen species
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