Definition of Natural T Cell Antigens with Mimicry Epitopes Obtained from Dedicated Synthetic Peptide Libraries

Progress has recently been made in the use of synthetic peptide libraries for the identification of T cell-stimulating ligands. T cell epitopes identified from synthetic libraries are mimics of natural epitopes. Here we show how the mimicry epitopes obtained from synthetic peptide libraries enable u...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-10, Vol.161 (8), p.4078-4082
Hauptverfasser:	Hiemstra, Hoebert S, van Veelen, Peter A, Schloot, Nanette C, Geluk, Annemieke, van Meijgaarden, Krista E, Willemen, Sabine J. M, Leunissen, Jack A. M, Benckhuijsen, Willemien E, Amons, Reinout, de Vries, Rene R. P, Roep, Bart O, Ottenhoff, Tom H. M, Drijfhout, Jan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - immunology Humans Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Molecular Mimicry Mycobacterium tuberculosis - immunology Peptide Library Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology
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